Previous published studies have identified a class of women, Normal Weight Obese women (NWO) with normal BMI and high fatcontent. An important role of Interieukin-15 (IL-15) has been documented in facilitating muscle proliferation and promoting fat depletion. Indeed the presence of three types of IL-15 receptor subunits in fat tissue suggests a direct effect on adipose tissue. We studied three single nucleotide polymorphisms (SNP) of IL-15R alpha receptor gene and investigated their relationship with NWO phenotype. We considered two classes of women according to their BMI and percent fat mass (%FAT), class 1: including 72 overweight-obese women (high BMI-high fat mass) and class 2: including 36 NWO (normal BMI, high fat mass). Three sites of Interieukin-15 receptor subunit cc gene were examined, located respectively in exon4, exon5 intron-exon border and exon7. Genotyping of the identified polymorphisms was performed by restriction fragment length polymorphism. Haplotype frequency estimation was performed by using the Mendel-University of Chicago program. Odds ratio analyses were calculated by EPISTAT program. Highly significant differences were observed for exon 7-exon5 intron-exon border and exon 4-exon 7 haplotype distribution between class 1,:and class 2 women. These results strongly support the hypothesis that genetic variability of the IL-15 receptor has an important role in body fat composition. Our data underscore previous findings that suggest a potential role of IL-15 cytokine in NWO syndrome.
Di Renzo, L., Gloria, F., Saccucci, P., Bigioni, M., Abenavoli, L., Gasbarrini, G., et al. (2009). Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 22(1), 105-113.
|Tipologia:||Articolo su rivista|
|Citazione:||Di Renzo, L., Gloria, F., Saccucci, P., Bigioni, M., Abenavoli, L., Gasbarrini, G., et al. (2009). Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 22(1), 105-113.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2009|
|Titolo:||Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome|
|Autori:||Di Renzo, L; Gloria, F; Saccucci, P; Bigioni, M; Abenavoli, L; Gasbarrini, G; De Lorenzo, A|
|Appare nelle tipologie:||01 - Articolo su rivista|