Previous published studies have identified a class of women, Normal Weight Obese women (NWO) with normal BMI and high fatcontent. An important role of Interieukin-15 (IL-15) has been documented in facilitating muscle proliferation and promoting fat depletion. Indeed the presence of three types of IL-15 receptor subunits in fat tissue suggests a direct effect on adipose tissue. We studied three single nucleotide polymorphisms (SNP) of IL-15R alpha receptor gene and investigated their relationship with NWO phenotype. We considered two classes of women according to their BMI and percent fat mass (%FAT), class 1: including 72 overweight-obese women (high BMI-high fat mass) and class 2: including 36 NWO (normal BMI, high fat mass). Three sites of Interieukin-15 receptor subunit cc gene were examined, located respectively in exon4, exon5 intron-exon border and exon7. Genotyping of the identified polymorphisms was performed by restriction fragment length polymorphism. Haplotype frequency estimation was performed by using the Mendel-University of Chicago program. Odds ratio analyses were calculated by EPISTAT program. Highly significant differences were observed for exon 7-exon5 intron-exon border and exon 4-exon 7 haplotype distribution between class 1,:and class 2 women. These results strongly support the hypothesis that genetic variability of the IL-15 receptor has an important role in body fat composition. Our data underscore previous findings that suggest a potential role of IL-15 cytokine in NWO syndrome.

DI RENZO, L., Gloria, F., Saccucci, P., Bigioni, M., Abenavoli, L., Gasbarrini, G., et al. (2009). Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 22(1), 105-113.

Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome

DI RENZO, LAURA;GLORIA, FULVIA;SACCUCCI, PATRIZIA;DE LORENZO, ANTONINO
2009-01-01

Abstract

Previous published studies have identified a class of women, Normal Weight Obese women (NWO) with normal BMI and high fatcontent. An important role of Interieukin-15 (IL-15) has been documented in facilitating muscle proliferation and promoting fat depletion. Indeed the presence of three types of IL-15 receptor subunits in fat tissue suggests a direct effect on adipose tissue. We studied three single nucleotide polymorphisms (SNP) of IL-15R alpha receptor gene and investigated their relationship with NWO phenotype. We considered two classes of women according to their BMI and percent fat mass (%FAT), class 1: including 72 overweight-obese women (high BMI-high fat mass) and class 2: including 36 NWO (normal BMI, high fat mass). Three sites of Interieukin-15 receptor subunit cc gene were examined, located respectively in exon4, exon5 intron-exon border and exon7. Genotyping of the identified polymorphisms was performed by restriction fragment length polymorphism. Haplotype frequency estimation was performed by using the Mendel-University of Chicago program. Odds ratio analyses were calculated by EPISTAT program. Highly significant differences were observed for exon 7-exon5 intron-exon border and exon 4-exon 7 haplotype distribution between class 1,:and class 2 women. These results strongly support the hypothesis that genetic variability of the IL-15 receptor has an important role in body fat composition. Our data underscore previous findings that suggest a potential role of IL-15 cytokine in NWO syndrome.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/04 - Patologia Generale
English
Con Impact Factor ISI
Interleukin-15; normal weight obese syndrome; single nucleotide polymorphisms; body fat; body mass; exon; gene structure; lipid composition; phenotype; obesity; body mass index; body weight; single nucleotide
DI RENZO, L., Gloria, F., Saccucci, P., Bigioni, M., Abenavoli, L., Gasbarrini, G., et al. (2009). Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 22(1), 105-113.
DI RENZO, L; Gloria, F; Saccucci, P; Bigioni, M; Abenavoli, L; Gasbarrini, G; DE LORENZO, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/8063
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