Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E-2 release and the upregulation of LPA(3) receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.

D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., et al. (2005). Activatory properties of lysophosphatidic acid on human THP-1 cells. INFLAMMATION(29), 129-140 [10.1007/s10753-006-9008-9].

Activatory properties of lysophosphatidic acid on human THP-1 cells

CAROTENUTO, FELICIA;DI NARDO, PAOLO;
2005-01-01

Abstract

Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E-2 release and the upregulation of LPA(3) receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - Medicina Interna
English
Con Impact Factor ISI
arachidonic acid metabolites; LPA receptors; lysophosphatidic acid; proliferation; reactive oxygen intermediates; lipid; prostaglandin E2; monocyte; mediator; leukocyte activation
D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., et al. (2005). Activatory properties of lysophosphatidic acid on human THP-1 cells. INFLAMMATION(29), 129-140 [10.1007/s10753-006-9008-9].
D'Aquilio, F; Procaccini, M; Izzi, V; Chiurchiu', V; Giambra, V; Carotenuto, F; DI NARDO, P; Baldini, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/8032
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