Excessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E-2 release and the upregulation of LPA(3) receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.
D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., et al. (2007). Activatory properties of lysophosphatidic acid on human THP-1 cells. INFLAMMATION, 30(5), 167-177.
Tipologia: | Articolo su rivista |
Citazione: | D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., et al. (2007). Activatory properties of lysophosphatidic acid on human THP-1 cells. INFLAMMATION, 30(5), 167-177. |
URL: | http://www.springerlink.com/content/r0005j5814034807/fulltext.pdf |
IF: | Con Impact Factor ISI |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore MED/05 - Patologia Clinica |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10753-007-9034-2 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2007 |
Titolo: | Activatory properties of lysophosphatidic acid on human THP-1 cells |
Autori: | |
Autori: | D'Aquilio, F; Procaccini, M; Izzi, V; Chiurchiu', V; Giambra, V; Carotenuto, F; Di Nardo, P; Baldini, PM |
Appare nelle tipologie: | 01 - Articolo su rivista |