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EnglishExcessive leukocyte proliferation and proinflammatory mediators release represent common phenomena in several chronic inflammatory diseases. Multiple evidences identify lysophosphatidic acid (LPA), a small lipid endowed with pleiotropic activities, as an important modulator of both proliferation and activation of different cell types involved in several inflammation-associated pathologies. However, its possible role on monocyte proinflammatory activation is not fully understood yet. Aim of the present study was to investigate LPA effects on THP-1 cells in terms of proliferation, reactive oxygen intermediates (ROI) production and release of arachidonic acid-derived inflammatory mediators. Actually, LPA significantly increased both DNA synthesis and ROI production as well as prostaglandin E-2 release and the upregulation of LPA(3) receptor expression. These findings identified LPA as both a growth factor and a triggering mediator of proinflammatory response in THP-1 cells.
D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., et al. (2007). Activatory properties of lysophosphatidic acid on human THP-1 cells. INFLAMMATION, 30(5), 167-177.
| Tipologia: | Articolo su rivista | |
| Citazione: | D'Aquilio, F., Procaccini, M., Izzi, V., Chiurchiu', V., Giambra, V., Carotenuto, F., et al. (2007). Activatory properties of lysophosphatidic acid on human THP-1 cells. INFLAMMATION, 30(5), 167-177. | |
| URL: | http://www.springerlink.com/content/r0005j5814034807/fulltext.pdf | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore MED/05 - Patologia Clinica | |
| Revisione (peer review): | Sì, ma tipo non specificato | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10753-007-9034-2 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 2007 | |
| Titolo: | Activatory properties of lysophosphatidic acid on human THP-1 cells | |
| Autori: | ||
| Autori: | D'Aquilio, F; Procaccini, M; Izzi, V; Chiurchiu', V; Giambra, V; Carotenuto, F; Di Nardo, P; Baldini, PM | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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