Due to the increasing use of engineered nanoparticles in many consumer products, rapid and economic tests for evaluating possible adverse effects on human health are urgently needed. In the present chapter the use of mouse embryonic stem cells as a valuable tool to in vitro screen nanoparticle toxicity on embryonic tissues is described. This in vitro method is a modification of the embryonic stem cell test, which has been widely used to screen soluble chemical compounds for their embryotoxic potential. The test offers an alternative to animal experimentation, reducing experimental costs and ethical issues.

Campagnolo, L., Fenoglio, I., Massimiani, M., Magrini, A., Pietroiusti, A. (2013). Screening of nanoparticle embryotoxicity using embryonic stem cells. In K. Turksen (a cura di), Stem cell nanotechnology (pp. 49-60). Humana Press [10.1007/7651_2013_11].

Screening of nanoparticle embryotoxicity using embryonic stem cells

CAMPAGNOLO, LUISA;MAGRINI, ANDREA;PIETROIUSTI, ANTONIO
2013-01-01

Abstract

Due to the increasing use of engineered nanoparticles in many consumer products, rapid and economic tests for evaluating possible adverse effects on human health are urgently needed. In the present chapter the use of mouse embryonic stem cells as a valuable tool to in vitro screen nanoparticle toxicity on embryonic tissues is described. This in vitro method is a modification of the embryonic stem cell test, which has been widely used to screen soluble chemical compounds for their embryotoxic potential. The test offers an alternative to animal experimentation, reducing experimental costs and ethical issues.
2013
Settore MED/44 - MEDICINA DEL LAVORO
Settore BIO/17 - ISTOLOGIA
English
Rilevanza internazionale
Capitolo o saggio
Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Survival; Embryonic Stem Cells; Mice; NIH 3T3 Cells; Nanoparticles
Campagnolo, L., Fenoglio, I., Massimiani, M., Magrini, A., Pietroiusti, A. (2013). Screening of nanoparticle embryotoxicity using embryonic stem cells. In K. Turksen (a cura di), Stem cell nanotechnology (pp. 49-60). Humana Press [10.1007/7651_2013_11].
Campagnolo, L; Fenoglio, I; Massimiani, M; Magrini, A; Pietroiusti, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/79892
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