Many in vitro studies demonstrated that metal oxide nanoparticles like zinc oxide and titanium dioxide are versatile platforms for industrial and biomedical applications. In this paper, investigation of the embryotoxic potential of these nanoparticles using the Embryonic stem Cells Test (EST) was evaluated. The EST is a validated in vitro toxicity test used to predict embryotoxicity of soluble chemical compounds, which only recently has been applied to nanoparticles, demonstrating its suitability also in nanotoxicology. Through such test, we were able to classify zinc oxide nanoparticles as not embryotoxic, while titanium dioxide nanoparticles appeared to be weakly embryotoxic.

Vecchione, L., Massimiani, M., Camaioni, A., Sifrani, L., Magrini, A., Pietroiusti, A., et al. (2013). A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test. BIONANOMATERIALS, 14, 61-64 [10.1515/bnm-2013-0008].

A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test

CAMAIONI, ANTONELLA;MAGRINI, ANDREA;PIETROIUSTI, ANTONIO;CAMPAGNOLO, LUISA
2013-08-06

Abstract

Many in vitro studies demonstrated that metal oxide nanoparticles like zinc oxide and titanium dioxide are versatile platforms for industrial and biomedical applications. In this paper, investigation of the embryotoxic potential of these nanoparticles using the Embryonic stem Cells Test (EST) was evaluated. The EST is a validated in vitro toxicity test used to predict embryotoxicity of soluble chemical compounds, which only recently has been applied to nanoparticles, demonstrating its suitability also in nanotoxicology. Through such test, we were able to classify zinc oxide nanoparticles as not embryotoxic, while titanium dioxide nanoparticles appeared to be weakly embryotoxic.
6-ago-2013
Pubblicato
Rilevanza internazionale
Lettera
Esperti anonimi
Settore BIO/17 - ISTOLOGIA
English
Vecchione, L., Massimiani, M., Camaioni, A., Sifrani, L., Magrini, A., Pietroiusti, A., et al. (2013). A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test. BIONANOMATERIALS, 14, 61-64 [10.1515/bnm-2013-0008].
Vecchione, L; Massimiani, M; Camaioni, A; Sifrani, L; Magrini, A; Pietroiusti, A; Campagnolo, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/79769
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