Erythrocyte glutathione transferase (e-GST) displays increased activity in patients with renal damage and positive correlation with homocysteine (Hcy) in patients under maintenance hemodialysis. Here, we determined e-GST, Hcy, and erythrocyte catalase (e-CAT) in 328 patients affected by type 2 diabetes mellitus (T2DM), 61 diabetic non-nephropathic patients and 267 affected by diabetes and by chronic kidney disease (CKD) under conservative therapy subdivided into four stages according to K-DOQI lines. e-GST activity was significantly higher in all T2DM patients compared to the control group (7.90 ± 0.26 vs. 5.6 ± 0.4 U/gHb), and we observed an enhanced activity in all subgroups of CKD diabetic patients. No significant correlation or increase has been found for e-CAT in all patients tested. Mean Hcy in diabetic patients is higher than that in healthy subjects (33.42 ± 1.23 vs. 13.6 ± 0.8 μM), and Hcy increases in relation to the CKD stage. As expected, a significant correlation was found between e-GST and Hcy levels. These findings suggest that e-GST hyperactivity is not caused directly by diabetes but by its consequent renal damage. e-GST, as well as Hcy, may represent an early biomarker of renal failure.
Noce, A., Fabrini, R., Dessi', M., Bocedi, A., Santini, S., Rovella, V., et al. (2013). Erythrocyte glutathione transferase activity: a possible early biomarker for blood toxicity in uremic diabetic patients. ACTA DIABETOLOGICA.
|Tipologia:||Articolo su rivista|
|Citazione:||Noce, A., Fabrini, R., Dessi', M., Bocedi, A., Santini, S., Rovella, V., et al. (2013). Erythrocyte glutathione transferase activity: a possible early biomarker for blood toxicity in uremic diabetic patients. ACTA DIABETOLOGICA.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore BIO/10|
Settore MED/09 - Medicina Interna
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00592-013-0497-3|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2-lug-2013|
|Titolo:||Erythrocyte glutathione transferase activity: a possible early biomarker for blood toxicity in uremic diabetic patients|
|Autori:||Noce, A; Fabrini, R; Dessi', M; Bocedi, A; Santini, S; Rovella, V; Pastore, A; Tesauro, M; Bernardini, S; DI DANIELE, N; Ricci, G|
|Appare nelle tipologie:||01 - Articolo su rivista|