The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1 α (PPARGC1A or PGC-1α) is a powerful controller of cell metabolism and assures the balance between the production and the scavenging of pro-oxidant molecules by coordinating mitochondrial biogenesis and the expression of antioxidants. However, even though a huge amount of data referring to the role of PGC-1α is available, the molecular mechanisms of its regulation at the transcriptional level are not completely understood. In the present report, we aim at characterizing whether the decrease of antioxidant glutathione (GSH) modulates PGC-1α expression and its downstream metabolic pathways.

Aquilano, K., Baldelli, S., Pagliei, B., Cannata, S., Rotilio, G., Ciriolo, M.r. (2013). p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance. ANTIOXIDANTS & REDOX SIGNALING, 18(4), 386-399 [10.1089/ars.2012.4615].

p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance

AQUILANO, KATIA;CANNATA, STEFANO;ROTILIO, GIUSEPPE;CIRIOLO, MARIA ROSA
2013-02-01

Abstract

The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1 α (PPARGC1A or PGC-1α) is a powerful controller of cell metabolism and assures the balance between the production and the scavenging of pro-oxidant molecules by coordinating mitochondrial biogenesis and the expression of antioxidants. However, even though a huge amount of data referring to the role of PGC-1α is available, the molecular mechanisms of its regulation at the transcriptional level are not completely understood. In the present report, we aim at characterizing whether the decrease of antioxidant glutathione (GSH) modulates PGC-1α expression and its downstream metabolic pathways.
1-feb-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
Con Impact Factor ISI
Superoxide Dismutase; Animals; Tumor Suppressor Protein p53; Antioxidants; Apoptosis; Glutathione; Humans; Glutamate-Cysteine Ligase; Transcription, Genetic; Mice; Protein Binding; Transcriptional Activation; Oxidation-Reduction; Nitric Oxide; Promoter Regions, Genetic; Transcription Factors; Oxidative Stress; Enzyme Induction; Adaptation, Physiological; Up-Regulation; Cell Line; Heat-Shock Proteins; NF-E2-Related Factor 2
Aquilano, K., Baldelli, S., Pagliei, B., Cannata, S., Rotilio, G., Ciriolo, M.r. (2013). p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance. ANTIOXIDANTS & REDOX SIGNALING, 18(4), 386-399 [10.1089/ars.2012.4615].
Aquilano, K; Baldelli, S; Pagliei, B; Cannata, S; Rotilio, G; Ciriolo, Mr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/79050
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