The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1 α (PPARGC1A or PGC-1α) is a powerful controller of cell metabolism and assures the balance between the production and the scavenging of pro-oxidant molecules by coordinating mitochondrial biogenesis and the expression of antioxidants. However, even though a huge amount of data referring to the role of PGC-1α is available, the molecular mechanisms of its regulation at the transcriptional level are not completely understood. In the present report, we aim at characterizing whether the decrease of antioxidant glutathione (GSH) modulates PGC-1α expression and its downstream metabolic pathways.
Aquilano, K., Baldelli, S., Pagliei, B., Cannata, S., Rotilio, G., Ciriolo, M.r. (2013). p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance. ANTIOXIDANTS & REDOX SIGNALING, 18(4), 386-399 [10.1089/ars.2012.4615].
p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance
AQUILANO, KATIA;CANNATA, STEFANO;ROTILIO, GIUSEPPE;CIRIOLO, MARIA ROSA
2013-02-01
Abstract
The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1 α (PPARGC1A or PGC-1α) is a powerful controller of cell metabolism and assures the balance between the production and the scavenging of pro-oxidant molecules by coordinating mitochondrial biogenesis and the expression of antioxidants. However, even though a huge amount of data referring to the role of PGC-1α is available, the molecular mechanisms of its regulation at the transcriptional level are not completely understood. In the present report, we aim at characterizing whether the decrease of antioxidant glutathione (GSH) modulates PGC-1α expression and its downstream metabolic pathways.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
