Saquinavir, a protease inhibitor utilized in HIV infection, shows antitumor activity in various experimental models. In previous studies performed in our laboratory the drug was found to induce a substantial increase of telomerase activity in normal peripheral blood mononuclear cells. Aim of the present investigation was to test whether saquinavir was able to increase telomerase activity and the expression of the catalytic subunit of telomerase, hTERT, in human malignant hematopoietic cells.
Adamo, R., Comandini, A., Aquino, A., Bonmassar, L., Guglielmi, L., Bonmassar, E., et al. (2013). The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 32, 38-38 [10.1186/1756-9966-32-38].
The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro
AQUINO, ANGELO;BONMASSAR, ENZO;FRANZESE, ORNELLA
2013-06-08
Abstract
Saquinavir, a protease inhibitor utilized in HIV infection, shows antitumor activity in various experimental models. In previous studies performed in our laboratory the drug was found to induce a substantial increase of telomerase activity in normal peripheral blood mononuclear cells. Aim of the present investigation was to test whether saquinavir was able to increase telomerase activity and the expression of the catalytic subunit of telomerase, hTERT, in human malignant hematopoietic cells.| File | Dimensione | Formato | |
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