Non-alcoholic fatty liver disease (NAFLD) has recently been recognized as the leading cause of the abnormalities in the liver function tests in the Western countries. Celiac disease (CD) is a permanent immunological intolerance to gluten proteins in genetically predisposed individuals. CD has been reported in 4-13 % of the cases with steatohepatitis, although the pathogenesis of the liver steatosis in CD patients is unclear. Based on the literature data, it can be concluded that the inclusion of serological markers of CD should be a part of the general workup in the patients with steatosis when other causes of the liver disease are excluded and in the patients with NAFLD when metabolic risk factors are not evident.

Abenavoli, L., Milic, N., DE LORENZO, A., Luzza, F. (2013). A pathogenetic link between non-alcoholic fatty liver disease and celiac disease. ENDOCRINE, 43(1), 65-67 [10.1007/s12020-012-9731-y].

A pathogenetic link between non-alcoholic fatty liver disease and celiac disease

DE LORENZO, ANTONINO;
2013-02-01

Abstract

Non-alcoholic fatty liver disease (NAFLD) has recently been recognized as the leading cause of the abnormalities in the liver function tests in the Western countries. Celiac disease (CD) is a permanent immunological intolerance to gluten proteins in genetically predisposed individuals. CD has been reported in 4-13 % of the cases with steatohepatitis, although the pathogenesis of the liver steatosis in CD patients is unclear. Based on the literature data, it can be concluded that the inclusion of serological markers of CD should be a part of the general workup in the patients with steatosis when other causes of the liver disease are excluded and in the patients with NAFLD when metabolic risk factors are not evident.
feb-2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
Settore MED/12 - GASTROENTEROLOGIA
English
Con Impact Factor ISI
Diet, Gluten-Free; Permeability; Intestines; Humans; Liver; Lipopolysaccharides; Gram-Positive Bacteria; Fatty Liver; Celiac Disease; Gram-Negative Bacteria
Abenavoli, L., Milic, N., DE LORENZO, A., Luzza, F. (2013). A pathogenetic link between non-alcoholic fatty liver disease and celiac disease. ENDOCRINE, 43(1), 65-67 [10.1007/s12020-012-9731-y].
Abenavoli, L; Milic, N; DE LORENZO, A; Luzza, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/78872
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