Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its activation is observed early in neural tube formation and persists during postnatal differentiation of the neural network. Caspase-3 activation, a crucial event of neuronal cell death program, is also a feature of many chronic neurodegenerative diseases. This traditional apoptotic function of caspase-3 is challenged by recent studies that reveal new cell death-independent roles for mitochondrial-activated caspase-3 in neurite pruning and synaptic plasticity. These findings underscore the need for further research into the mechanism of action and functions of caspase-3 that may prove useful in the development of novel pharmacological treatments for a diverse range of neurological disorders.

D'Amelio, M., Sheng, M., Cecconi, F. (2012). Caspase-3 in the central nervous system: beyond apoptosis. TRENDS IN NEUROSCIENCES, 35(11), 700-709 [10.1016/j.tins.2012.06.004].

Caspase-3 in the central nervous system: beyond apoptosis

CECCONI, FRANCESCO
2012-11-01

Abstract

Caspase-3 has been identified as a key mediator of neuronal programmed cell death. This protease plays a central role in the developing nervous system and its activation is observed early in neural tube formation and persists during postnatal differentiation of the neural network. Caspase-3 activation, a crucial event of neuronal cell death program, is also a feature of many chronic neurodegenerative diseases. This traditional apoptotic function of caspase-3 is challenged by recent studies that reveal new cell death-independent roles for mitochondrial-activated caspase-3 in neurite pruning and synaptic plasticity. These findings underscore the need for further research into the mechanism of action and functions of caspase-3 that may prove useful in the development of novel pharmacological treatments for a diverse range of neurological disorders.
nov-2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/06 - ANATOMIA COMPARATA E CITOLOGIA
English
Con Impact Factor ISI
Embryonic Development; Long-Term Synaptic Depression; Animals; Apoptosis; Enzyme Activation; Humans; Alzheimer Disease; Molecular Targeted Therapy; Apoptosis Regulatory Proteins; Caspase 3; Mitochondria; Disease Models, Animal; Nervous System; Mice; Nerve Tissue Proteins; Nerve Net; Mice, Knockout; Caspase Inhibitors; Parkinson Disease; Neurons; Neural Tube; Receptors, N-Methyl-D-Aspartate; Huntington Disease
D'Amelio, M., Sheng, M., Cecconi, F. (2012). Caspase-3 in the central nervous system: beyond apoptosis. TRENDS IN NEUROSCIENCES, 35(11), 700-709 [10.1016/j.tins.2012.06.004].
D'Amelio, M; Sheng, M; Cecconi, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/78053
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