Abstract: The use of bacterial lysates to reduce acute exacerbations of COPD (AECOPDs) is an intriguing concept. Bacterial lysates are powerful inducers of a specific immune response against bacterial infections, but their mechanism of action is not fully understood. Apparently, they lower bacterial carriage levels in the respiratory tract, decrease the incidence and severity of exacerbations, decrease hospitalizations owing to exacerbations, and reduce the need for antibiotics. Unfortunately, almost all trials conducted to date are small and methodologically flawed. Further studies are needed to produce a greater level of evidence that can support the recommendation for a more widely use of bacterial lysates as a prophylactic treatment of AECOPDs.

Cazzola, M., Capuano, A., Rogliani, P., Matera, M. (2012). Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD. CURRENT OPINION IN PHARMACOLOGY, 12(3), 300-308 [10.1016/j.coph.2012.01.019].

Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD.

CAZZOLA, MARIO;ROGLIANI, PAOLA;
2012-06-01

Abstract

Abstract: The use of bacterial lysates to reduce acute exacerbations of COPD (AECOPDs) is an intriguing concept. Bacterial lysates are powerful inducers of a specific immune response against bacterial infections, but their mechanism of action is not fully understood. Apparently, they lower bacterial carriage levels in the respiratory tract, decrease the incidence and severity of exacerbations, decrease hospitalizations owing to exacerbations, and reduce the need for antibiotics. Unfortunately, almost all trials conducted to date are small and methodologically flawed. Further studies are needed to produce a greater level of evidence that can support the recommendation for a more widely use of bacterial lysates as a prophylactic treatment of AECOPDs.
giu-2012
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO
English
Cazzola, M., Capuano, A., Rogliani, P., Matera, M. (2012). Bacterial lysates as a potentially effective approach in preventing acute exacerbation of COPD. CURRENT OPINION IN PHARMACOLOGY, 12(3), 300-308 [10.1016/j.coph.2012.01.019].
Cazzola, M; Capuano, A; Rogliani, P; Matera, Mgc
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/78020
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