Current evidence on routine immunization of HIV-1 infected children point out the need for a special vaccine schedule in this population. However, optimal strategies for identifying individuals susceptible to infections, and then offering them sustained protection through appropriate immunization schedule, both in terms of timing and number of vaccine doses, still remain to be elucidated. Understanding the degree of immune recovery after HAART initiation is important in guiding administration of routine vaccination in HIV-1 infected children. Although quantitative measures (e.g., CD4+ T-cell counts and immunoglobulin levels) are frequently performed to evaluate immune parameters, these measures do not fully mirror functional immune recovery. Here, we will review the status of single mandatory and recommended vaccines for HIV-1 infected children in relation to immune recovery after HAART initiation with the aim of identifying new means to help design personalized vaccine schedules for this population.

Cagigi, A., Cotugno, N., Giaquinto, C., Nicolosi, L., Bernardi, S., Rossi, P., et al. (2012). Immune reconstitution and vaccination outcome in HIV-1 infected children: present knowledge and future directions. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 8(12), 1784-1794 [10.4161/hv.21827].

Immune reconstitution and vaccination outcome in HIV-1 infected children: present knowledge and future directions

Cotugno, N;ROSSI, PAOLO;Palma, P.
2012-12-01

Abstract

Current evidence on routine immunization of HIV-1 infected children point out the need for a special vaccine schedule in this population. However, optimal strategies for identifying individuals susceptible to infections, and then offering them sustained protection through appropriate immunization schedule, both in terms of timing and number of vaccine doses, still remain to be elucidated. Understanding the degree of immune recovery after HAART initiation is important in guiding administration of routine vaccination in HIV-1 infected children. Although quantitative measures (e.g., CD4+ T-cell counts and immunoglobulin levels) are frequently performed to evaluate immune parameters, these measures do not fully mirror functional immune recovery. Here, we will review the status of single mandatory and recommended vaccines for HIV-1 infected children in relation to immune recovery after HAART initiation with the aim of identifying new means to help design personalized vaccine schedules for this population.
dic-2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
immunization schedule; AIDS; protective immune responses; HAART; vertical infection
Cagigi, A., Cotugno, N., Giaquinto, C., Nicolosi, L., Bernardi, S., Rossi, P., et al. (2012). Immune reconstitution and vaccination outcome in HIV-1 infected children: present knowledge and future directions. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 8(12), 1784-1794 [10.4161/hv.21827].
Cagigi, A; Cotugno, N; Giaquinto, C; Nicolosi, L; Bernardi, S; Rossi, P; Douagi, I; Palma, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/77867
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