Genetic studies indicate that distinct signaling modulators are each necessary but not individually sufficient for embryonic hepatocyte survival in vivo. Nevertheless, how signaling players are interconnected into functional circuits and how they coordinate the balance of cell survival and death in developing livers are still major unresolved issues. In the present study, we examined the modulation of the p53 pathway by HGF/Met in embryonic livers.
Furlan, A., Lamballe, F., Stagni, V., Hussain, A., Richelme, S., Prodosmo, A., et al. (2012). Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. JOURNAL OF HEPATOLOGY, 57(6), 1292-1298 [10.1016/j.jhep.2012.07.044].
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver
BARILA', DANIELA;
2012-12-01
Abstract
Genetic studies indicate that distinct signaling modulators are each necessary but not individually sufficient for embryonic hepatocyte survival in vivo. Nevertheless, how signaling players are interconnected into functional circuits and how they coordinate the balance of cell survival and death in developing livers are still major unresolved issues. In the present study, we examined the modulation of the p53 pathway by HGF/Met in embryonic livers.| File | Dimensione | Formato | |
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