The transcription factor nuclear factor-erythroid-derived 2-like 2 (official symbol: NFE2L2, alias: Nrf2) is a master regulator of antioxidant defense system, which makes it an attractive target for manipulations that aim to increase cellular resistance to oxidative stress. Nuclear respiratory factor 2 or GA binding protein transcription factor alpha (official symbol: GABPA, alias: NRF2) functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for mitochondrial respiration as well as mitochondrial DNA transcription and replication.
Baldelli, S., Aquilano, K., Ciriolo, M.r. (2013). Punctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2. BIOCHIMICA ET BIOPHYSICA ACTA, 1830(8), 4137-4146 [10.1016/j.bbagen.2013.04.006].
Punctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2
AQUILANO, KATIA;CIRIOLO, MARIA ROSA
2013-08-01
Abstract
The transcription factor nuclear factor-erythroid-derived 2-like 2 (official symbol: NFE2L2, alias: Nrf2) is a master regulator of antioxidant defense system, which makes it an attractive target for manipulations that aim to increase cellular resistance to oxidative stress. Nuclear respiratory factor 2 or GA binding protein transcription factor alpha (official symbol: GABPA, alias: NRF2) functions as a transcription factor that activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for mitochondrial respiration as well as mitochondrial DNA transcription and replication.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
