Antimicrobial peptides usually kill bacteria by making their membranes permeable. Two main models (barrel-stave and Shai-Matsuzaki-Huang) have been proposed to describe the peptide-induced pores. Although several experimental tests can be exploited to discriminate between these two models, the dependence of peptide activity on lipid properties (intrinsic curvature and membrane thickness) is routinely used for this purpose. Here, we show that, contrary to what is currently accepted, this criterion is unreliable.

Bobone, S., Roversi, D., Giordano, L., De Zotti, M., Formaggio, F., Toniolo, C., et al. (2012). The Lipid Dependence of Antimicrobial Peptide Activity Is an Unreliable Experimental Test for Different Pore Models. BIOCHEMISTRY, 51, 10124-10126 [10.1021/bi3015086].

The Lipid Dependence of Antimicrobial Peptide Activity Is an Unreliable Experimental Test for Different Pore Models

Bobone, S;STELLA, LORENZO
2012-01-01

Abstract

Antimicrobial peptides usually kill bacteria by making their membranes permeable. Two main models (barrel-stave and Shai-Matsuzaki-Huang) have been proposed to describe the peptide-induced pores. Although several experimental tests can be exploited to discriminate between these two models, the dependence of peptide activity on lipid properties (intrinsic curvature and membrane thickness) is routinely used for this purpose. Here, we show that, contrary to what is currently accepted, this criterion is unreliable.
2012
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/02 - CHIMICA FISICA
English
Con Impact Factor ISI
Rapid Report. Selezionato per essere evidenziato sulla home page della rivista
Bobone, S., Roversi, D., Giordano, L., De Zotti, M., Formaggio, F., Toniolo, C., et al. (2012). The Lipid Dependence of Antimicrobial Peptide Activity Is an Unreliable Experimental Test for Different Pore Models. BIOCHEMISTRY, 51, 10124-10126 [10.1021/bi3015086].
Bobone, S; Roversi, D; Giordano, L; De Zotti, M; Formaggio, F; Toniolo, C; Stella, L
Articolo su rivista
File in questo prodotto:
File Dimensione Formato  
Biochemistry2012.pdf

accesso aperto

Licenza: Copyright dell'editore
Dimensione 2.82 MB
Formato Adobe PDF
2.82 MB Adobe PDF Visualizza/Apri

Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons Creative Commons

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/76768
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 24
social impact