Cells are continually exposed to DNA assaults from exogenous and endogenous sources. To maintain genomic integrity, cells have evolved a highly conserved mechanism for repairing DNA lesions and, in particular, DNA double strand breaks (DSBs). Emerging evidence indicates that DNA repair/signaling machinery acts in an integrated fashion with chromatin structure at damaged sites. This review focuses on the interplay between histone modifications and the chromatin-mediated response to DNA damage.
Gonfloni, S. (2013). Targeting DNA damage response: threshold, chromatin landscape and beyond. PHARMACOLOGY & THERAPEUTICS, 138(1), 46-52 [10.1016/j.pharmthera.2012.12.006].
Targeting DNA damage response: threshold, chromatin landscape and beyond
GONFLONI, STEFANIA
2013-01-04
Abstract
Cells are continually exposed to DNA assaults from exogenous and endogenous sources. To maintain genomic integrity, cells have evolved a highly conserved mechanism for repairing DNA lesions and, in particular, DNA double strand breaks (DSBs). Emerging evidence indicates that DNA repair/signaling machinery acts in an integrated fashion with chromatin structure at damaged sites. This review focuses on the interplay between histone modifications and the chromatin-mediated response to DNA damage.| File | Dimensione | Formato | |
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