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EnglishA patient classified as HCV-1a positive by both LiPA Siemens 2.0 and Abbott RealTime HCV-Genotype II, was instead infected with HCV-1g, as determined by phylogenetic-analysis of NS3-sequences. HCV-1g NS3-sequences to date available naturally harbor the resistance-substitution T54S, plus P131S and L135F changes, located in the highly conserved NS3-positions within boceprevir-binding site, as determined by structural modeling. HCV-1g NS3-sequences show some similarities to HCV-4, poorly responsive to interferon/ribavirin and to boceprevir/telaprevir; this patient was also a null-responder to boceprevir-treatment. Baseline genotypic-resistance testing may provide critical information for the management of first-generation protease-inhibitors based regimens, including both HCV genotype/subtype and natural resistance.
Cento, V., Landonio, S., De Luca, F., Di Maio, V., Micheli, V., Mirabelli, C., et al. (2013). A boceprevir failure in a patient infected with HCV-genotype 1g: importance and limitations of virus genotyping prior to HCV protease inhibitor-based therapy. ANTIVIRAL THERAPY.
| Tipologia: | Articolo su rivista |
| Citazione: | Cento, V., Landonio, S., De Luca, F., Di Maio, V., Micheli, V., Mirabelli, C., et al. (2013). A boceprevir failure in a patient infected with HCV-genotype 1g: importance and limitations of virus genotyping prior to HCV protease inhibitor-based therapy. ANTIVIRAL THERAPY. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3851/IMP2529 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 15-feb-2013 |
| Titolo: | A boceprevir failure in a patient infected with HCV-genotype 1g: importance and limitations of virus genotyping prior to HCV protease inhibitor-based therapy |
| Autori: | |
| Autori: | Cento, V; Landonio, S; De Luca, F; Di Maio, V; Micheli, V; Mirabelli, C; Niero, F; Magni, C; Rizzardini, G; Perno, C; Ceccherini-Silberstein, F |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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