In order to characterize the biological effects and molecular mechanism underlying indocyanine-green (ICG)-mediated photo-oxidative cell damage, human cultured retinal pigmented epithelium (RPE) cells preloaded with ICG were exposed to 810-nm laser irradiation. Cell viability and death induction were examined, as well as the modulation of proteins involved in cell death and DNA repair.

Ricci, F., Pucci, S., Sesti, F., Missiroli, F., Cerulli, L., Spagnoli, L.g. (2007). Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. OPHTHALMIC RESEARCH, 39(3), 164-173 [10.1159/000103236].

Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage

RICCI, FEDERICO;PUCCI, SABINA;SESTI, FRANCESCO;MISSIROLI, FILIPPO;CERULLI, LUCIANO;SPAGNOLI, LUIGI GIUSTO
2007-01-01

Abstract

In order to characterize the biological effects and molecular mechanism underlying indocyanine-green (ICG)-mediated photo-oxidative cell damage, human cultured retinal pigmented epithelium (RPE) cells preloaded with ICG were exposed to 810-nm laser irradiation. Cell viability and death induction were examined, as well as the modulation of proteins involved in cell death and DNA repair.
2007
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
English
Apoptosis; DNA Repair; Pigment Epithelium of Eye; bcl-2-Associated X Protein; DNA-Binding Proteins; Humans; Photochemotherapy; Gene Expression; Clusterin; Antigens, Nuclear; Indocyanine Green; Coloring Agents; Blotting, Western; Oxidative Stress; Cell Death; DNA; Lasers; Immunohistochemistry
Ricci, F., Pucci, S., Sesti, F., Missiroli, F., Cerulli, L., Spagnoli, L.g. (2007). Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. OPHTHALMIC RESEARCH, 39(3), 164-173 [10.1159/000103236].
Ricci, F; Pucci, S; Sesti, F; Missiroli, F; Cerulli, L; Spagnoli, Lg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/70742
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