MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity.

Mercatelli, N., Coppola, V., Bonci, D., Miele, F., Costantini, A., Guadagnoli, M., et al. (2008). The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLOS ONE, 3(12), e4029-e4029 [10.1371/journal.pone.0004029].

The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice

MERCATELLI, NERI;SPAGNOLI, LUIGI GIUSTO;CIAFRE', SILVIA ANNA
2008-01-01

Abstract

MiR-221 and miR-222 are two highly homologous microRNAs whose upregulation has been recently described in several types of human tumors, for some of which their oncogenic role was explained by the discovery of their target p27, a key cell cycle regulator. We previously showed this regulatory relationship in prostate carcinoma cell lines in vitro, underlying the role of miR-221/222 as inducers of proliferation and tumorigenicity.
2008
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - ANATOMIA PATOLOGICA
English
Animals; Proliferating Cell Nuclear Antigen; MicroRNAs; Humans; Disease Progression; Aged; Mice; Gene Therapy; Cell Proliferation; Oligonucleotides; Carcinoma; Gene Expression Regulation, Neoplastic; Base Sequence; Tumor Cells, Cultured; Down-Regulation; Xenograft Model Antitumor Assays; Middle Aged; Mice, SCID; Prostatic Neoplasms; Male
Mercatelli, N., Coppola, V., Bonci, D., Miele, F., Costantini, A., Guadagnoli, M., et al. (2008). The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLOS ONE, 3(12), e4029-e4029 [10.1371/journal.pone.0004029].
Mercatelli, N; Coppola, V; Bonci, D; Miele, F; Costantini, A; Guadagnoli, M; Bonanno, E; Muto, G; Frajese, G; De Maria, R; Spagnoli, Lg; Farace, M; Ciafre', Sa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/70737
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