The identification of useful markers for early diagnosis of human colon cancer is a major goal still in progress. Clusterin is a pleiotropic protein with a broad range of functions. It has recently drawn much attention because of its association with cancer promotion and metastasis. It is involved in prosurvival and apoptosis processes that are carried out by two different isoforms. Secreted clusterin isoform (sCLU) is cytoprotective and its prosurvival function is the basis of the current phase I/II clinical trials against prostate, lung, and breast cancers. We have already shown that in colorectal cancer (CRC) there is an increased expression of sCLU. In this report, we investigated whether sCLU is released in the blood and stool of colon cancer patients in order to study sCLU as a potential diagnostic molecular marker for colon cancer screening.

Pucci, S., Bonanno, E., Sesti, F., Mazzarelli, P., Mauriello, A., Ricci, F., et al. (2009). Clusterin in stool: a new biomarker for colon cancer screening?. THE AMERICAN JOURNAL OF GASTROENTEROLOGY, 104(11), 2807-2815 [10.1038/ajg.2009.412].

Clusterin in stool: a new biomarker for colon cancer screening?

PUCCI, SABINA;BONANNO, ELENA;MAZZARELLI, PAOLA;MAURIELLO, ALESSANDRO;RICCI, FEDERICO;RULLI, FRANCESCO;SPAGNOLI, LUIGI GIUSTO
2009-11-01

Abstract

The identification of useful markers for early diagnosis of human colon cancer is a major goal still in progress. Clusterin is a pleiotropic protein with a broad range of functions. It has recently drawn much attention because of its association with cancer promotion and metastasis. It is involved in prosurvival and apoptosis processes that are carried out by two different isoforms. Secreted clusterin isoform (sCLU) is cytoprotective and its prosurvival function is the basis of the current phase I/II clinical trials against prostate, lung, and breast cancers. We have already shown that in colorectal cancer (CRC) there is an increased expression of sCLU. In this report, we investigated whether sCLU is released in the blood and stool of colon cancer patients in order to study sCLU as a potential diagnostic molecular marker for colon cancer screening.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/08 - Anatomia Patologica
English
Sensitivity and Specificity; Animals; Probability; Humans; Clusterin; Aged; Pilot Projects; Feasibility Studies; Aged, 80 and over; Adult; Early Detection of Cancer; Enzyme-Linked Immunosorbent Assay; Feces; Tumor Markers, Biological; Male; ROC Curve; Biopsy, Needle; Age Distribution; Mass Screening; Colonoscopy; Blotting, Western; Incidence; Follow-Up Studies; Middle Aged; Sex Distribution; Colonic Neoplasms; Immunohistochemistry; Statistics, Nonparametric; Colorectal Neoplasms; Female
Pucci, S., Bonanno, E., Sesti, F., Mazzarelli, P., Mauriello, A., Ricci, F., et al. (2009). Clusterin in stool: a new biomarker for colon cancer screening?. THE AMERICAN JOURNAL OF GASTROENTEROLOGY, 104(11), 2807-2815 [10.1038/ajg.2009.412].
Pucci, S; Bonanno, E; Sesti, F; Mazzarelli, P; Mauriello, A; Ricci, F; Zoccai, G; Rulli, F; Galatà, G; Spagnoli, Lg
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/70718
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