Multiple myeloma still remains a fatal disease. However, in the last months new biological and clinical informations have been provided about this disease. In particular, the immunophenotype of myeloma cells seems indicate, in some patients, a clonal involvement of a stem cell in the pathogenesis of myeloma. Moreover, new biological insights concerning the cytokine network, have revealed a probable effect of some cytokines, such as IL6, IL3, IL4. Finally, new insights in the biology of multiple myeloma have been provided by studies of molecular biology and flow cytometry. As for therapy, the best conventional induction treatment still remains to be defined. In the last years, the increased use of alpha Interferon and new therapeutic modalities, such as transplantation procedures in multiple myeloma, open new hopes toward a cure of this disease. Therefore, in the future a better knowledge of the multiple myeloma biology, associated with a wider use of new effective therapeutic approaches will certainly improve the natural course of this disease.

Coppetelli, U., Avvisati, G., Tribalto, M., Cantonetti, M., La Verde, G., Petrucci, T., et al. (1992). Biological and clinical advances in multiple myeloma: A review. RECENTI PROGRESSI IN MEDICINA, 83(9), 520-527.

Biological and clinical advances in multiple myeloma: A review

TRIBALTO, MAURIZIO;CANTONETTI, MARIA;
1992-01-01

Abstract

Multiple myeloma still remains a fatal disease. However, in the last months new biological and clinical informations have been provided about this disease. In particular, the immunophenotype of myeloma cells seems indicate, in some patients, a clonal involvement of a stem cell in the pathogenesis of myeloma. Moreover, new biological insights concerning the cytokine network, have revealed a probable effect of some cytokines, such as IL6, IL3, IL4. Finally, new insights in the biology of multiple myeloma have been provided by studies of molecular biology and flow cytometry. As for therapy, the best conventional induction treatment still remains to be defined. In the last years, the increased use of alpha Interferon and new therapeutic modalities, such as transplantation procedures in multiple myeloma, open new hopes toward a cure of this disease. Therefore, in the future a better knowledge of the multiple myeloma biology, associated with a wider use of new effective therapeutic approaches will certainly improve the natural course of this disease.
Pubblicato
Rilevanza internazionale
Articolo
Nessuno
Settore MED/15 - Malattie del Sangue
Settore MED/06 - Oncologia Medica
English
EMTREE drug terms: alpha interferon; carmustine; cyclophosphamide; doxorubicin; melphalan; prednisone; semustine; vincristine EMTREE medical terms: human; multiple myeloma; oral drug administration; review MeSH: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; English Abstract; Human; Interferon-alpha; Karyotyping; Melphalan; Multiple Myeloma; Phenotype; Prednisone; Prospective Studies; Randomized Controlled Trials
Coppetelli, U., Avvisati, G., Tribalto, M., Cantonetti, M., La Verde, G., Petrucci, T., et al. (1992). Biological and clinical advances in multiple myeloma: A review. RECENTI PROGRESSI IN MEDICINA, 83(9), 520-527.
Coppetelli, U; Avvisati, G; Tribalto, M; Cantonetti, M; La Verde, G; Petrucci, T; Stasi, R; Papa, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/69283
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