Bortezomib and rituximab have shown additive activity in preclinical models of lymphoma, and have been shown to be active and generally well tolerated in a randomised phase 2 study in patients with follicular and marginal zone lymphoma. We compared the efficacy and safety of rituximab alone or combined with bortezomib in patients with relapsed or refractory follicular lymphoma in a phase 3 setting.

Coiffier, B., Osmanov, E., Hong, X., Scheliga, A., Mayer, J., Offner, F., et al. (2011). Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial. THE LANCET ONCOLOGY, 12(8), 773-784 [10.1016/S1470-2045(11)70150-4].

Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial

CANTONETTI, MARIA;
2011-08-01

Abstract

Bortezomib and rituximab have shown additive activity in preclinical models of lymphoma, and have been shown to be active and generally well tolerated in a randomised phase 2 study in patients with follicular and marginal zone lymphoma. We compared the efficacy and safety of rituximab alone or combined with bortezomib in patients with relapsed or refractory follicular lymphoma in a phase 3 setting.
ago-2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/15 - MALATTIE DEL SANGUE
Settore MED/06 - ONCOLOGIA MEDICA
English
Con Impact Factor ISI
Young Adult; Disease-Free Survival; Neoplasm Staging; Antineoplastic Agents; Humans; Lymphoma, Follicular; Aged; Recurrence; Pyrazines; Infusion Pumps; Aged, 80 and over; Adult; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Middle Aged; Female; Male; Antibodies, Monoclonal, Murine-Derived
Coiffier, B., Osmanov, E., Hong, X., Scheliga, A., Mayer, J., Offner, F., et al. (2011). Bortezomib plus rituximab versus rituximab alone in patients with relapsed, rituximab-naive or rituximab-sensitive, follicular lymphoma: a randomised phase 3 trial. THE LANCET ONCOLOGY, 12(8), 773-784 [10.1016/S1470-2045(11)70150-4].
Coiffier, B; Osmanov, E; Hong, X; Scheliga, A; Mayer, J; Offner, F; Rule, S; Teixeira, A; Walewski, J; de Vos, S; Crump, M; Shpilberg, O; Esseltine, D...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/69202
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