The cytokine-activated Janus Kinase (JAK)- Signal Transducer and Activator of Transcription (STAT) pathway is the principal signalling mechanism for a wide array of cytokines and growth factors. JAK activation stimulates cell proliferation, differentiation, cell migration and apoptosis. Dysregulation of JAK- STAT signalling is associated with various pathological disorders. The signalling strength, kinetics and specificity of the JAK- STAT pathway are modulated at many levels by distinct regulatory proteins. Recently, different PKC isoforms have been implied in the regulation of proteins involved in Jak-STAT pathway. In my laboratory is been demonstrated that inhibition of cPKC activity impairs STAT activation and IFN-alpha±- induced gene expression. Here, I reported that cPKC activation is generally required for JAK-STAT signalling pathway activation. Moreover, I shown evidences for a direct regulation of the JAKs activity by cPKC through conformational modification via phosphorylation in the pseudokinase domain.

Di Croce, M. (2008). Ruolo della protein chinasi C nella via di trasduzione del segnale Jak-STAT indotta dall' interferone alfa.

Ruolo della protein chinasi C nella via di trasduzione del segnale Jak-STAT indotta dall' interferone alfa

2008-11-13

Abstract

The cytokine-activated Janus Kinase (JAK)- Signal Transducer and Activator of Transcription (STAT) pathway is the principal signalling mechanism for a wide array of cytokines and growth factors. JAK activation stimulates cell proliferation, differentiation, cell migration and apoptosis. Dysregulation of JAK- STAT signalling is associated with various pathological disorders. The signalling strength, kinetics and specificity of the JAK- STAT pathway are modulated at many levels by distinct regulatory proteins. Recently, different PKC isoforms have been implied in the regulation of proteins involved in Jak-STAT pathway. In my laboratory is been demonstrated that inhibition of cPKC activity impairs STAT activation and IFN-alpha±- induced gene expression. Here, I reported that cPKC activation is generally required for JAK-STAT signalling pathway activation. Moreover, I shown evidences for a direct regulation of the JAKs activity by cPKC through conformational modification via phosphorylation in the pseudokinase domain.
A.A. 2006/2007
protein chinasi C (Protein Kinase C; PKC)
conventional protein kinase C (cPKC)
Jak-STAT pathway
Jak kinase (Janus protein tyrosine Kinase)
Interferone alfa (IFNα) Transcription
citochine
interleuchina 6 (IL-6)
interleuchina 22 (IL-22)
Settore BIO/13
it
Tesi di dottorato
Di Croce, M. (2008). Ruolo della protein chinasi C nella via di trasduzione del segnale Jak-STAT indotta dall' interferone alfa.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/690
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