PURPOSE: This study evaluated the usefulness of 3-Tesla magnetic resonance (MR) spectroscopy in patients with non-Hodgkin's lymphoma (NHL) undergoing bone marrow transplantation (BMT). MATERIALS AND METHODS: Twelve NHL patients who were candidates for BMT underwent three MR examinations of the lumbosacral spine: before ablative therapy for BMT, 15±4 days and 54±24 days after BMT. The MR study was supplemented by spectroscopic analysis. The lipid content was calculated and expressed as a percentage of lipid signal intensity relative to total signal intensity [fat fraction (FF)]. RESULTS: In the first MR study, the FF was 62.5±7%, in the second it was 70.75±5% and in the third it was 75±1%. We observed a statistically significant difference between FF values calculated at the various MR studies (p=0.02) and between red blood cell count (p=0.017), platelet count (p=0.003) and haematocrit (p<0.001) at the three MR studies. FF had a statistically significant correlation with the number of circulating platelets (p<0.01) CONCLUSIONS: MR spectroscopy of the bone marrow of NHL patients undergoing BMT is noninvasive and highly sensitive for characterising and monitoring bone marrow after BMT.

Sergiacomi, G., Gaspari, E., Taglieri, A., Meschini, A., Gisone, V., Cudillo, L., et al. (2013). 3-Tesla MR spectroscopy in patients subjected to bone marrow transplantation: clinical correlations. LA RADIOLOGIA MEDICA, 118(1), 101-111 [10.1007/s11547-012-0796-8].

3-Tesla MR spectroscopy in patients subjected to bone marrow transplantation: clinical correlations.

SERGIACOMI, GIANLUIGI;CUDILLO, LAURA;ARCESE, WILLIAM;SIMONETTI, GIOVANNI MARIA EGISTO
2013

Abstract

PURPOSE: This study evaluated the usefulness of 3-Tesla magnetic resonance (MR) spectroscopy in patients with non-Hodgkin's lymphoma (NHL) undergoing bone marrow transplantation (BMT). MATERIALS AND METHODS: Twelve NHL patients who were candidates for BMT underwent three MR examinations of the lumbosacral spine: before ablative therapy for BMT, 15±4 days and 54±24 days after BMT. The MR study was supplemented by spectroscopic analysis. The lipid content was calculated and expressed as a percentage of lipid signal intensity relative to total signal intensity [fat fraction (FF)]. RESULTS: In the first MR study, the FF was 62.5±7%, in the second it was 70.75±5% and in the third it was 75±1%. We observed a statistically significant difference between FF values calculated at the various MR studies (p=0.02) and between red blood cell count (p=0.017), platelet count (p=0.003) and haematocrit (p<0.001) at the three MR studies. FF had a statistically significant correlation with the number of circulating platelets (p<0.01) CONCLUSIONS: MR spectroscopy of the bone marrow of NHL patients undergoing BMT is noninvasive and highly sensitive for characterising and monitoring bone marrow after BMT.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/15 - Malattie del Sangue
Settore MED/36 - Diagnostica per Immagini e Radioterapia
English
Con Impact Factor ISI
Bone marrow transplantation; 3-Tesla magnetic resonance; Spectroscopy
Sergiacomi, G., Gaspari, E., Taglieri, A., Meschini, A., Gisone, V., Cudillo, L., et al. (2013). 3-Tesla MR spectroscopy in patients subjected to bone marrow transplantation: clinical correlations. LA RADIOLOGIA MEDICA, 118(1), 101-111 [10.1007/s11547-012-0796-8].
Sergiacomi, G; Gaspari, E; Taglieri, A; Meschini, A; Gisone, V; Cudillo, L; Arcese, W; Simonetti, Gme
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/68924
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