Acute graft-versus-host disease (GVHD) results from reactivity of donor immunocompetent cells versus host tissues. Its pathogenesis involves co-stimulatory molecules, cytokines, free radicals, and oxidative stress products. N-Acetylcysteine (NAC) is an antioxidant that inhibits the B7-1/CD28 expression in vitro, and it may contrabalance the effects of free radicals and oxidative stress; it has been tested in eight patients with steroid-resistant acute GVHD.

Colombo, A., Alessandrino, E., Bernasconi, P., Arcese, G., Rabusin, M., Bacigalupo, A., et al. (1999). N-acetylcysteine in the treatment of steroid-resistant acute graft-versus-host-disease: preliminary results. Gruppo Italiano Trapianto di Midollo Osseo (GITMO). TRANSPLANTATION, 68(9), 1414-1416 [10.1097/00007890-199911150-00031].

N-acetylcysteine in the treatment of steroid-resistant acute graft-versus-host-disease: preliminary results. Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

ARCESE, WILLIAM
1999-11-15

Abstract

Acute graft-versus-host disease (GVHD) results from reactivity of donor immunocompetent cells versus host tissues. Its pathogenesis involves co-stimulatory molecules, cytokines, free radicals, and oxidative stress products. N-Acetylcysteine (NAC) is an antioxidant that inhibits the B7-1/CD28 expression in vitro, and it may contrabalance the effects of free radicals and oxidative stress; it has been tested in eight patients with steroid-resistant acute GVHD.
15-nov-1999
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/15 - MALATTIE DEL SANGUE
English
Con Impact Factor ISI
Acute Disease; Antioxidants; Humans; Adult; Graft vs Host Disease; Drug Resistance; Acetylcysteine; Middle Aged; Adolescent; Male; Female; Adrenal Cortex Hormones
Colombo, A., Alessandrino, E., Bernasconi, P., Arcese, G., Rabusin, M., Bacigalupo, A., et al. (1999). N-acetylcysteine in the treatment of steroid-resistant acute graft-versus-host-disease: preliminary results. Gruppo Italiano Trapianto di Midollo Osseo (GITMO). TRANSPLANTATION, 68(9), 1414-1416 [10.1097/00007890-199911150-00031].
Colombo, A; Alessandrino, E; Bernasconi, P; Arcese, G; Rabusin, M; Bacigalupo, A; Bernasconi, C; Arcese, W
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/68782
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