Host’s resistance against tuberculosis relies on classical MHC-dependent immunity and on CD1-restricted responses against non-peptide antigens (e.g. mycolic acid) presented by cytokine-activated monocytes (CAM) to CD3+, CD4–/CD8– (i.e.,double-negative, DN) T cells. A number of antitubercular or anti-HIV agents do not impair the in vitro induction of CD1b molecule by GM-CSF on normal monocytes, or the functional activity of DNT cells. However, azydothymidine reduces CAM number, whereas Rifampin increases CD1b expression. These results point out that immunopharmacological analysis of chemotherapeutic agents should include the CD1-dependent immune system.
Bonmassar, E., Aquino, A., Giuliani, A., Porcelli, S., Tentori, L., Prete, S., et al. (1998). New aspects of immune responses against mycobacteria: immunopharmacology studies. HAEMATOLOGICA, 83(meeting supplement), 58-60.
New aspects of immune responses against mycobacteria: immunopharmacology studies
AQUINO, ANGELO;TENTORI, LUCIO;PRETE, SALVATORE;GRAZIANI, GRAZIA
1998-01-01
Abstract
Host’s resistance against tuberculosis relies on classical MHC-dependent immunity and on CD1-restricted responses against non-peptide antigens (e.g. mycolic acid) presented by cytokine-activated monocytes (CAM) to CD3+, CD4–/CD8– (i.e.,double-negative, DN) T cells. A number of antitubercular or anti-HIV agents do not impair the in vitro induction of CD1b molecule by GM-CSF on normal monocytes, or the functional activity of DNT cells. However, azydothymidine reduces CAM number, whereas Rifampin increases CD1b expression. These results point out that immunopharmacological analysis of chemotherapeutic agents should include the CD1-dependent immune system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
