The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM interval on 6p. Multipoint linkage analysis and haplotypes from recombinants map SCA1 between two of these markers, D6S274 and D6S259, 5-6 cM apart. A single rare four marker haplotype within this interval shows linkage disequilibrium with the disease locus in southern Italy and is transmitted with SCA1 in five kindreds originating from this area.

Iodice, C., Frontali, M., Persichetti, F., Novelletto, A., Pandolfo, M., Spadaro, M., et al. (1993). The gene for spinal cerebellar ataxia 1 (SCA1) is flanked by two closely linked highly polymorphic microsatellite loci. HUMAN MOLECULAR GENETICS, 2, 1383-1387.

The gene for spinal cerebellar ataxia 1 (SCA1) is flanked by two closely linked highly polymorphic microsatellite loci

IODICE, CARLA;NOVELLETTO, ANDREA;MALASPINA, PATRIZIA;TERRENATO, LUCIANO
1993-01-01

Abstract

The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM interval on 6p. Multipoint linkage analysis and haplotypes from recombinants map SCA1 between two of these markers, D6S274 and D6S259, 5-6 cM apart. A single rare four marker haplotype within this interval shows linkage disequilibrium with the disease locus in southern Italy and is transmitted with SCA1 in five kindreds originating from this area.
1993
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/18 - GENETICA
Settore MED/03 - GENETICA MEDICA
English
Con Impact Factor ISI
Iodice, C., Frontali, M., Persichetti, F., Novelletto, A., Pandolfo, M., Spadaro, M., et al. (1993). The gene for spinal cerebellar ataxia 1 (SCA1) is flanked by two closely linked highly polymorphic microsatellite loci. HUMAN MOLECULAR GENETICS, 2, 1383-1387.
Iodice, C; Frontali, M; Persichetti, F; Novelletto, A; Pandolfo, M; Spadaro, M; Giunti, P; Schinaia, G; Lulli, P; Malaspina, P; Plasmati, R; Tola, R; ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/68337
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