Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and from models based on the overexpression of mutant SOD1 found in a small subset of patients, clearly point to mitochondrial damage as a relevant facet of this neurodegenerative condition. In this mini-review we provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function'.
Cozzolino, M., Ferri, A., Valle, C., Carri', M.t. (2013). Mitochondria and ALS: Implications from novel genes and pathways. MOLECULAR AND CELLULAR NEUROSCIENCES, 55, 44-49 [10.1016/j.mcn.2012.06.001].
Mitochondria and ALS: Implications from novel genes and pathways
CARRI', MARIA TERESA
2013-06-15
Abstract
Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and from models based on the overexpression of mutant SOD1 found in a small subset of patients, clearly point to mitochondrial damage as a relevant facet of this neurodegenerative condition. In this mini-review we provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function'.File | Dimensione | Formato | |
---|---|---|---|
MolCellNeurosci2012.pdf
solo utenti autorizzati
Licenza:
Non specificato
Dimensione
533.09 kB
Formato
Adobe PDF
|
533.09 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.