A 59 year old male presented with a 4 month history of lower urinary tract symptoms. Exhaustive urological investigations revealed papillary tumors and carcinoma in situ extending from the prostatic urethra, throughout the bladder, up both ureters and into the renal pelves. Tumors were resected where possible and then bacillus Calmette-Guèrin (BCG) and mitomycin C (MMC) were infused sequentially through bilateral nephrostomy tubes for a total of six BCG and three MMC instillations. Follow up 1 month post treatment demonstrated a complete response which persisted for 2 years. Then there appeared a solitary papillomatous recurrence in the bladder which was successfully resected. Side effects were the occasional fever and BCG induced granulomatous prostatitis which slowly resolved. In conclusion, sequential BCG/MMC instillations were effective treatment for widespread panurothelial carcinomatosis.

DI STASI, S.m., Giannantoni, A., Stephen, R., Storti, L., Attisani, F., Sansalone, S., et al. (2005). Percutaneous sequential bacillus Calmette-Guèrin and mitomycin C for panurothelial carcinomatosis, 12(6), 2895-2898.

Percutaneous sequential bacillus Calmette-Guèrin and mitomycin C for panurothelial carcinomatosis

DI STASI, SAVINO MAURO;SANSALONE, SALVATORE;VIRGILI, GUIDO
2005-12-01

Abstract

A 59 year old male presented with a 4 month history of lower urinary tract symptoms. Exhaustive urological investigations revealed papillary tumors and carcinoma in situ extending from the prostatic urethra, throughout the bladder, up both ureters and into the renal pelves. Tumors were resected where possible and then bacillus Calmette-Guèrin (BCG) and mitomycin C (MMC) were infused sequentially through bilateral nephrostomy tubes for a total of six BCG and three MMC instillations. Follow up 1 month post treatment demonstrated a complete response which persisted for 2 years. Then there appeared a solitary papillomatous recurrence in the bladder which was successfully resected. Side effects were the occasional fever and BCG induced granulomatous prostatitis which slowly resolved. In conclusion, sequential BCG/MMC instillations were effective treatment for widespread panurothelial carcinomatosis.
dic-2005
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/24 - UROLOGIA
English
Drug Therapy, Combination; BCG Vaccine; Nephrostomy, Percutaneous; Humans; Mitomycin; Adjuvants, Immunologic; Middle Aged; Urologic Neoplasms; Antibiotics, Antineoplastic; Male; Carcinoma
DI STASI, S.m., Giannantoni, A., Stephen, R., Storti, L., Attisani, F., Sansalone, S., et al. (2005). Percutaneous sequential bacillus Calmette-Guèrin and mitomycin C for panurothelial carcinomatosis, 12(6), 2895-2898.
DI STASI, Sm; Giannantoni, A; Stephen, R; Storti, L; Attisani, F; Sansalone, S; Virgili, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/68036
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