Telomerase is a ribonucleoprotein enzyme which is involved in the maintenance of chromosome ends. Telomerase activity (TLMA) is required for cell immortality and can be considered a ubiquitous tumor marker. In this study we describe a new approach for developing in vitro chemosensitivity assays based on the assessment of TLMA in tumors, upon treatment with antineoplastic agents. The results of preliminary studies on in vitro cultured tumor cell lines indicate that TLMA inhibition can be used as a marker of tumor cell killing by anticancer drugs. Therefore the present investigation provides the rational basis for an in vitro chemosensitivity assay based on TLMA evaluation.

Faraoni, I., Turriziani, M., Bonmasssar, E., DE VECCHIS, L., Graziani, G. (1996). Development of a novel in vitro chemosensitivity assay: telomerase as a possible marker of tumor cell survival. JOURNAL OF CHEMOTHERAPY, 8(5), 394-398.

Development of a novel in vitro chemosensitivity assay: telomerase as a possible marker of tumor cell survival

FARAONI, ISABELLA;TURRIZIANI, MARIO;DE VECCHIS, LIANA;GRAZIANI, GRAZIA
1996-10-01

Abstract

Telomerase is a ribonucleoprotein enzyme which is involved in the maintenance of chromosome ends. Telomerase activity (TLMA) is required for cell immortality and can be considered a ubiquitous tumor marker. In this study we describe a new approach for developing in vitro chemosensitivity assays based on the assessment of TLMA in tumors, upon treatment with antineoplastic agents. The results of preliminary studies on in vitro cultured tumor cell lines indicate that TLMA inhibition can be used as a marker of tumor cell killing by anticancer drugs. Therefore the present investigation provides the rational basis for an in vitro chemosensitivity assay based on TLMA evaluation.
ott-1996
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Cell Count; Antineoplastic Agents; Telomerase; Humans; Thiazoles; Carmustine; Jurkat Cells; Tetrazolium Salts; Cell Survival; Coloring Agents; Tumor Cells, Cultured; Antineoplastic Agents, Alkylating; Tumor Markers, Biological
Faraoni, I., Turriziani, M., Bonmasssar, E., DE VECCHIS, L., Graziani, G. (1996). Development of a novel in vitro chemosensitivity assay: telomerase as a possible marker of tumor cell survival. JOURNAL OF CHEMOTHERAPY, 8(5), 394-398.
Faraoni, I; Turriziani, M; Bonmasssar, E; DE VECCHIS, L; Graziani, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/68016
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