Membrane potential responses to acetylcholine (ACh, 10(-7)-10(-3 M) were investigated in monkey and rabbit ovarian oocytes. In monkey oocytes ACh most commonly elicited a short-latency hyperpolarization concomitant with a decreased membrane input resistance (Rin). Under voltage-clamp short-latency ACh currents had an equilibrium potential of approximately -40 mV. In rabbit oocytes responses to ACh consisted of an increase in Rin or of a depolarization with an equilibrium potential of approximately -15 mV. Curare, hexamethonium, and atropine (10(-5)-10(-3) M) did not block these ACh responses. Thus, the oocyte membrane in the rabbit contains ACh receptors that cannot be classified as either muscarinic or nicotinic.

Caratsch, C., Eusebi, F., Salustri, A. (1984). Acetylcholine receptors in monkey and rabbit oocytes. JOURNAL OF CELLULAR PHYSIOLOGY, 121(2), 415-418 [10.1002/jcp.1041210220].

Acetylcholine receptors in monkey and rabbit oocytes

SALUSTRI, ANTONIETTA
1984

Abstract

Membrane potential responses to acetylcholine (ACh, 10(-7)-10(-3 M) were investigated in monkey and rabbit ovarian oocytes. In monkey oocytes ACh most commonly elicited a short-latency hyperpolarization concomitant with a decreased membrane input resistance (Rin). Under voltage-clamp short-latency ACh currents had an equilibrium potential of approximately -40 mV. In rabbit oocytes responses to ACh consisted of an increase in Rin or of a depolarization with an equilibrium potential of approximately -15 mV. Curare, hexamethonium, and atropine (10(-5)-10(-3) M) did not block these ACh responses. Thus, the oocyte membrane in the rabbit contains ACh receptors that cannot be classified as either muscarinic or nicotinic.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/17
English
Con Impact Factor ISI
Animals; Macaca fascicularis; Electric Conductivity; Evoked Potentials; Oocytes; Membrane Potentials; Rabbits; Acetylcholine; Receptors, Cholinergic; Female
Caratsch, C., Eusebi, F., Salustri, A. (1984). Acetylcholine receptors in monkey and rabbit oocytes. JOURNAL OF CELLULAR PHYSIOLOGY, 121(2), 415-418 [10.1002/jcp.1041210220].
Caratsch, C; Eusebi, F; Salustri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/67150
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