To verify the usefulness of Tc-99m tetrofosmin scintigraphy in the follow-up of breast cancer patients, we studied 72 surgically treated breast cancer patients with suspected local recurrences (20 cases) or distant metastases (52 cases) at clinical examination and/or at conventional imaging procedures (CIPs). In all patients, a whole-body scan followed by planar and single photon emission tomography (SPET) images of selected sites were acquired 10 min after the intravenous injection of 740 MBq of Tc-99m tetrofosmin, using a rectangular dual-head gamma camera equipped with high-resolution parallel-hole collimators. Loco-regional recurrences were diagnosed in 19 patients and distant metastases in 44 cases, while benign lesions were ascertained in nine cases. Tc-99m tetrofosmin SPET showed higher sensitivity, specificity and accuracy per patient than did CIP (96.8% vs 85%, 77.7% vs 55.5% and 94.4% vs 81.1%, respectively) with statistical significance for accuracy (P<0.05). The combined use of SPET and CIP achieved 100% sensitivity and 98.6% accuracy. Planar imaging did not give additional information in respect of either SPET or CIP, showing significantly lower sensitivity and accuracy values (47.6% and 52.8%, respectively). Our data seem to suggest that Tc-99m tetrofosmin SPET, but not planar, may be useful in the follow-up for the detection of loco-regional and distant recurrences in patients with breast cancer. The technique can play a complementary role to conventional diagnostic imaging procedures in selected patients. ((C) 2003 Lippincott Williams & Wilkins).

Spanu, A., Farris, A., Schillaci, O., Chessa, F., Solinas, M.E., Falchi, A., et al. (2003). The usefulness of Tc-99m tetrofosmin scintigraphy in patients with breast cancer recurrences. NUCLEAR MEDICINE COMMUNICATIONS, 24(2), 145-154.

The usefulness of Tc-99m tetrofosmin scintigraphy in patients with breast cancer recurrences

SCHILLACI, ORAZIO;
2003

Abstract

To verify the usefulness of Tc-99m tetrofosmin scintigraphy in the follow-up of breast cancer patients, we studied 72 surgically treated breast cancer patients with suspected local recurrences (20 cases) or distant metastases (52 cases) at clinical examination and/or at conventional imaging procedures (CIPs). In all patients, a whole-body scan followed by planar and single photon emission tomography (SPET) images of selected sites were acquired 10 min after the intravenous injection of 740 MBq of Tc-99m tetrofosmin, using a rectangular dual-head gamma camera equipped with high-resolution parallel-hole collimators. Loco-regional recurrences were diagnosed in 19 patients and distant metastases in 44 cases, while benign lesions were ascertained in nine cases. Tc-99m tetrofosmin SPET showed higher sensitivity, specificity and accuracy per patient than did CIP (96.8% vs 85%, 77.7% vs 55.5% and 94.4% vs 81.1%, respectively) with statistical significance for accuracy (P<0.05). The combined use of SPET and CIP achieved 100% sensitivity and 98.6% accuracy. Planar imaging did not give additional information in respect of either SPET or CIP, showing significantly lower sensitivity and accuracy values (47.6% and 52.8%, respectively). Our data seem to suggest that Tc-99m tetrofosmin SPET, but not planar, may be useful in the follow-up for the detection of loco-regional and distant recurrences in patients with breast cancer. The technique can play a complementary role to conventional diagnostic imaging procedures in selected patients. ((C) 2003 Lippincott Williams & Wilkins).
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/36 - Diagnostica per Immagini e Radioterapia
English
Con Impact Factor ISI
Tc-99m tetrofosmin; SPET; breast cancer; follow-up
POSITRON-EMISSION-TOMOGRAPHY; PROGNOSTIC FACTORS; IN-VITRO; FDG PET; TC-99M-TETROFOSMIN; MAMMOGRAPHY; CARCINOMA; TECHNETIUM-99M-TETROFOSMIN; DIAGNOSIS; LESIONS
Spanu, A., Farris, A., Schillaci, O., Chessa, F., Solinas, M.E., Falchi, A., et al. (2003). The usefulness of Tc-99m tetrofosmin scintigraphy in patients with breast cancer recurrences. NUCLEAR MEDICINE COMMUNICATIONS, 24(2), 145-154.
Spanu, A; Farris, A; Schillaci, O; Chessa, F; Solinas, M; Falchi, A; Madeddu, G; Nuvoli, S; Madeddu, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/67126
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