Impairment of cell-mediated immunity in patients with primary central nervous system (CNS) tumors has repeatedly been reported but data to demonstrate the underlying immunological defect are not univocal. This report concerns a series of 31 patients harboring a glioma in which we studied: peripheral blood T-lymphocyte subpopulations by monoclonal antibody analysis; cellular responsiveness to mitogens; serum immunoglobulin values. The same parameters were also evaluated in 7 cases of intracranial meningioma and in 8 patients affected by non-proliferative, non-inflammatory CNS diseases. Thirty age-matched healthy volunteers formed the control group. Neither impairment of T-cells as regard to number, responsiveness and subsets, nor abnormal Ig values were found in these groups. However two patients, harboring respectively a third ventricle low grade astrocytoma and an anterior callosal glioblastoma, presented a striking T-cells impairment. These findings might suggest a correlation between hypothalamus and immune system, as already postulated by several previous experimental and clinical studies.

Palma, L., Moschese, V., Galli, E., Barbieri, C., Lombardi, V., Rossi, P. (1987). Immunological studies in patients with central nervous system tumors. JOURNAL OF NEURO-ONCOLOGY, 5(1), 29-35 [10.1007/BF00162762].

Immunological studies in patients with central nervous system tumors

MOSCHESE, VIVIANA;ROSSI, PAOLO
1987-01-01

Abstract

Impairment of cell-mediated immunity in patients with primary central nervous system (CNS) tumors has repeatedly been reported but data to demonstrate the underlying immunological defect are not univocal. This report concerns a series of 31 patients harboring a glioma in which we studied: peripheral blood T-lymphocyte subpopulations by monoclonal antibody analysis; cellular responsiveness to mitogens; serum immunoglobulin values. The same parameters were also evaluated in 7 cases of intracranial meningioma and in 8 patients affected by non-proliferative, non-inflammatory CNS diseases. Thirty age-matched healthy volunteers formed the control group. Neither impairment of T-cells as regard to number, responsiveness and subsets, nor abnormal Ig values were found in these groups. However two patients, harboring respectively a third ventricle low grade astrocytoma and an anterior callosal glioblastoma, presented a striking T-cells impairment. These findings might suggest a correlation between hypothalamus and immune system, as already postulated by several previous experimental and clinical studies.
1987
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Con Impact Factor ISI
Lymphocyte Activation; Antibodies, Monoclonal; Brain Neoplasms; Hypothalamus; Humans; Adult; Middle Aged; Adolescent; Male; Female; T-Lymphocytes
Palma, L., Moschese, V., Galli, E., Barbieri, C., Lombardi, V., Rossi, P. (1987). Immunological studies in patients with central nervous system tumors. JOURNAL OF NEURO-ONCOLOGY, 5(1), 29-35 [10.1007/BF00162762].
Palma, L; Moschese, V; Galli, E; Barbieri, C; Lombardi, V; Rossi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/67014
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