It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.

Galli, E., Picardo, M., Chini, L., Passi, S., Moschese, V., Terminali, O., et al. (1994). Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease?. BRITISH JOURNAL OF DERMATOLOGY, 130(6), 752-756 [10.1111/j.1365-2133.1994.tb03413.x].

Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease?

CHINI, LOREDANA;MOSCHESE, VIVIANA;PAONE, FRANCESCO MARIA;ROSSI, PAOLO
1994-06

Abstract

It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - Pediatria Generale e Specialistica
eng
Con Impact Factor ISI
Dermatitis, Atopic; Breast Feeding; Humans; Infant, Newborn; Asthma; Fatty Acids, Unsaturated; 8,11,14-Eicosatrienoic Acid; Fetal Blood; Immunoglobulin E; Hypersensitivity, Immediate; Follow-Up Studies; Neonatal Screening; Male; Arachidonic Acid; Biological Markers; Female
Galli, E., Picardo, M., Chini, L., Passi, S., Moschese, V., Terminali, O., et al. (1994). Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease?. BRITISH JOURNAL OF DERMATOLOGY, 130(6), 752-756 [10.1111/j.1365-2133.1994.tb03413.x].
Galli, E; Picardo, M; Chini, L; Passi, S; Moschese, V; Terminali, O; Paone, Fm; Fraioli, G; Rossi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/66971
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