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DE FELICI, M. (2012). Origin, migration and proliferation of human primordial germ cells. In L.D.S. G. Coticchio (a cura di), Mammalian Oogenesis. Spinger.

Origin, migration and proliferation of human primordial germ cells

DE FELICI, MASSIMO
2012-01-01
2012
Settore BIO/17 - ISTOLOGIA
English
Rilevanza internazionale
Capitolo o saggio
The first histological observations about the origin of the precursors of the gametes termed the primordial germ cells (PGCs) in extragonadal regions and their subsequent migration into the developing gonads in human embryos date back to the early twentieth century. Fuss (1911, 1912) and Felix (1911), were apparently the first to describe the extragonadal location of PGCs in human embryos. In the youngest 2.5 mm long embryo examined (23-26 days post fertilization), Fuss described PGCs in the endoderm of the wall of the yolk sac as cells identifiable by their large size and spherical shape. Subsequently, Politzer (1928, 1930, 1933) and Witschi (1948) studied the distribution of PGCs in a considerable number of embryos from pre-somite stages (0.3-0.8 mm, about 3 weeks) to 8.5 mm (5 weeks). Both authors described the migration of PGCs from the yolk sac to the developing gonads. After hot debate, it is now generally accepted that after their arrival into the gonadal anlage, PGCs give rise to the oogonia/oocytes and gonocytes (or prespermatogonia) in the embryonic ovary and testis, respectively; these germ cells enter a complex series of events that in the adult end with the formation of fertilizable oocytes and sperm. Because the inaccessibility of the human embryo to experimental investigations at these early stages, we still know little about the cellular and molecular mechanisms controlling the formation, differentiation and development of human PGCs. This chapter describes the history life of human PGCs combining old and new information and when useful referring to the most recent results obtained in the mouse.
DE FELICI, M. (2012). Origin, migration and proliferation of human primordial germ cells. In L.D.S. G. Coticchio (a cura di), Mammalian Oogenesis. Spinger.
DE FELICI, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66932
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