The influence of electric charged molecules on the early phases of enterovirus infection was studied in order to select antiviral compounds able to prevent viral attachment. The effect of different polyelectrolytes on the multiplication of coxsackie virus B3, echovirus 6 and hepatitis A virus was investigated in susceptible cells by adding the drug before, during or after the viral adsorption period. Among polyanions, the polysaccharides heparin and dextran sulfate inhibited viral infectivity, dextran sulfate being the most effective mainly towards hepatitis A virus infection. DEAE-dextran and protamine sulfate, generally recognized as enhancers of infectivity of naked and enveloped viruses, exhibited an inhibitory effect towards the three picornaviruses tested. Only in the case of hepatitis A did DEAE-dextran slightly improve viral antigen synthesis. The inhibitory effect shown by compounds belonging to positive and negative polyions suggests that the electric charge is not sufficient by itself to explain the antiviral activity of these drugs.

Mastromarino, P., Seganti, L., Petruzziello, R., Gabrieli, R., Divizia, M., Pana', A., et al. (1991). Influence of polyions on the early steps of enterovirus infection. JOURNAL OF CHEMOTHERAPY, 3(4), 203-208.

Influence of polyions on the early steps of enterovirus infection

GABRIELI, ROSANNA;DIVIZIA, MAURIZIO;PANA', AUGUSTO;
1991-08-01

Abstract

The influence of electric charged molecules on the early phases of enterovirus infection was studied in order to select antiviral compounds able to prevent viral attachment. The effect of different polyelectrolytes on the multiplication of coxsackie virus B3, echovirus 6 and hepatitis A virus was investigated in susceptible cells by adding the drug before, during or after the viral adsorption period. Among polyanions, the polysaccharides heparin and dextran sulfate inhibited viral infectivity, dextran sulfate being the most effective mainly towards hepatitis A virus infection. DEAE-dextran and protamine sulfate, generally recognized as enhancers of infectivity of naked and enveloped viruses, exhibited an inhibitory effect towards the three picornaviruses tested. Only in the case of hepatitis A did DEAE-dextran slightly improve viral antigen synthesis. The inhibitory effect shown by compounds belonging to positive and negative polyions suggests that the electric charge is not sufficient by itself to explain the antiviral activity of these drugs.
ago-1991
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/42 - IGIENE GENERALE E APPLICATA
English
Animals; Anions; HeLa Cells; Humans; Hepatovirus; Enterovirus B, Human; Echovirus Infections; Cations; Cells, Cultured; Cercopithecus aethiops; Echovirus 6, Human; Cell Membrane; Hepatitis A; Vero Cells; Coxsackievirus Infections; Enterovirus Infections
Mastromarino, P., Seganti, L., Petruzziello, R., Gabrieli, R., Divizia, M., Pana', A., et al. (1991). Influence of polyions on the early steps of enterovirus infection. JOURNAL OF CHEMOTHERAPY, 3(4), 203-208.
Mastromarino, P; Seganti, L; Petruzziello, R; Gabrieli, R; Divizia, M; Pana', A; Orsi, N
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66671
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