The effect of lipophilic amines on hepatitis A virus infection in a monkey cell line (Frp/3 cells) was studied. Ammonium chloride, amantadine, methylamine and dansylcadaverine inhibited viral antigen synthesis when added to the cells at least one hour after the attachment step. Results obtained suggest that the HAV entry pathway in Frp/3 cells follows an endocytic route and that viral uncoating takes probably place in endosomes and/or lysosomes.

Superti, F., Seganti, L., Orsi, N., Divizia, M., Gabrieli, R., Panà, A. (1987). The effect of lipophilic amines on the growth of hepatitis A virus in Frp/3 cells. ARCHIVES OF VIROLOGY, 96(3-4), 289-296.

The effect of lipophilic amines on the growth of hepatitis A virus in Frp/3 cells

DIVIZIA, MAURIZIO;GABRIELI, ROSANNA;
1987-01-01

Abstract

The effect of lipophilic amines on hepatitis A virus infection in a monkey cell line (Frp/3 cells) was studied. Ammonium chloride, amantadine, methylamine and dansylcadaverine inhibited viral antigen synthesis when added to the cells at least one hour after the attachment step. Results obtained suggest that the HAV entry pathway in Frp/3 cells follows an endocytic route and that viral uncoating takes probably place in endosomes and/or lysosomes.
1987
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/42 - IGIENE GENERALE E APPLICATA
English
Endocytosis; Animals; Cadaverine; Hepatovirus; Cytopathogenic Effect, Viral; Amantadine; Diamines; Methylamines; Lysosomes; Haplorhini; Cell Line; Ammonium Chloride
Superti, F., Seganti, L., Orsi, N., Divizia, M., Gabrieli, R., Panà, A. (1987). The effect of lipophilic amines on the growth of hepatitis A virus in Frp/3 cells. ARCHIVES OF VIROLOGY, 96(3-4), 289-296.
Superti, F; Seganti, L; Orsi, N; Divizia, M; Gabrieli, R; Panà, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66626
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