A fast-growing strain of Human Hepatitis A (HHA) virus was selected by progressively shortening by the time between serial passages of the isolate in the simian cell line Frp/3. The virus so selected infected 90-95% of the cells in 7-10 days, and developed a strong cytopathic effect (CPE). The synthesis of HHA-specific antigens and the CPE were neutralized simultaneously by standard anti-HHA sera. This fast-growing strain has the characteristics of a picornavirus.

Divizia, M., Ruggeri, F., Hentschel, J., Flehmig, B., Panà, A., Perez Bercoff, R. (1986). Preliminary characterization of a fast-growing strain of human hepatitis A virus. MICROBIOLOGICA, 9(3), 269-278.

Preliminary characterization of a fast-growing strain of human hepatitis A virus

DIVIZIA, MAURIZIO;
1986-07-01

Abstract

A fast-growing strain of Human Hepatitis A (HHA) virus was selected by progressively shortening by the time between serial passages of the isolate in the simian cell line Frp/3. The virus so selected infected 90-95% of the cells in 7-10 days, and developed a strong cytopathic effect (CPE). The synthesis of HHA-specific antigens and the CPE were neutralized simultaneously by standard anti-HHA sera. This fast-growing strain has the characteristics of a picornavirus.
lug-1986
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/42 - IGIENE GENERALE E APPLICATA
English
Animals; Humans; Neutralization Tests; Hepatovirus; Enzyme-Linked Immunosorbent Assay; Antigens, Viral; Microscopy, Electron; Cytopathogenic Effect, Viral; RNA, Viral; Cell Line
Divizia, M., Ruggeri, F., Hentschel, J., Flehmig, B., Panà, A., Perez Bercoff, R. (1986). Preliminary characterization of a fast-growing strain of human hepatitis A virus. MICROBIOLOGICA, 9(3), 269-278.
Divizia, M; Ruggeri, F; Hentschel, J; Flehmig, B; Panà, A; Perez Bercoff, R
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66624
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