Murine L cells lacking thymidine kinase activity (Ltk-) do not respond to the antiviral or antiproliferative activity of interferon, whereas human tk- cells show a normal response. Furthermore, a clone of tk+ cells derived from Ltk- cells by DNA-mediated transfer of the tk herpes gene does not respond to interferon. Cells of this clone and Ltk- cells do not produce interferon when infected with Newcastle disease virus or treated with poly(I) X poly(C) and DEAE-dextran. Possible reasons for this inability to produce interferon and the lack of response to interferon are discussed.
Divizia, M., Baglioni, C. (1984). Lack of correlation between thymidine kinase activity and the antiviral or antiproliferative response to interferon. VIROLOGY, 133(1), 216-219.
Lack of correlation between thymidine kinase activity and the antiviral or antiproliferative response to interferon
DIVIZIA, MAURIZIO;
1984-02-01
Abstract
Murine L cells lacking thymidine kinase activity (Ltk-) do not respond to the antiviral or antiproliferative activity of interferon, whereas human tk- cells show a normal response. Furthermore, a clone of tk+ cells derived from Ltk- cells by DNA-mediated transfer of the tk herpes gene does not respond to interferon. Cells of this clone and Ltk- cells do not produce interferon when infected with Newcastle disease virus or treated with poly(I) X poly(C) and DEAE-dextran. Possible reasons for this inability to produce interferon and the lack of response to interferon are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
