EEG and evoked potential (EP) recordings of a female (aged 70) affected with Jakob-Creutzfeldt disease (JCD) are reported. A comparison of neurophysiological tests under basal conditions and pharmacological stimulation with methylphenidate, diazepam and piracetam was performed. Diazepam and methylphenidate produced a flattening of triphasic complexes and changes in background activity; piracetam did not seem to influence the abnormal brain bioelectrical environment. The authors conclude that EEG and EP abnormalities in JCD can be ascribed to two separate and interacting sources: (1) exaggerated massive excitatory input coming from a deep thalamic pace-maker throughout the diffuse projecting system, and (2) lack of inhibitory intracortical mechanisms.

Rossini, P., Caltagirone, C., David, P., Macchi, G. (1979). Jakob-Creutzfeldt disease: analysis of EEG and evoked potentials under basal conditions and neuroactive drugs. EUROPEAN NEUROLOGY, 18(4), 269-279.

Jakob-Creutzfeldt disease: analysis of EEG and evoked potentials under basal conditions and neuroactive drugs

CALTAGIRONE, CARLO;
1979-01-01

Abstract

EEG and evoked potential (EP) recordings of a female (aged 70) affected with Jakob-Creutzfeldt disease (JCD) are reported. A comparison of neurophysiological tests under basal conditions and pharmacological stimulation with methylphenidate, diazepam and piracetam was performed. Diazepam and methylphenidate produced a flattening of triphasic complexes and changes in background activity; piracetam did not seem to influence the abnormal brain bioelectrical environment. The authors conclude that EEG and EP abnormalities in JCD can be ascribed to two separate and interacting sources: (1) exaggerated massive excitatory input coming from a deep thalamic pace-maker throughout the diffuse projecting system, and (2) lack of inhibitory intracortical mechanisms.
1979
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
English
Injections, Intravenous; Diazepam; Humans; Pyrrolidinones; Electroencephalography; Clinical Trials as Topic; Aged; Creutzfeldt-Jakob Syndrome; Methylphenidate; Cerebral Cortex; Evoked Potentials; Piracetam; Placebos
Rossini, P., Caltagirone, C., David, P., Macchi, G. (1979). Jakob-Creutzfeldt disease: analysis of EEG and evoked potentials under basal conditions and neuroactive drugs. EUROPEAN NEUROLOGY, 18(4), 269-279.
Rossini, P; Caltagirone, C; David, P; Macchi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66605
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