The effect of 6,4'-dichloroflavan and of isoflavan and isoflavene derivatives on hepatitis A virus (HAV) infection in a monkey cell line (Frp/3 cells) was studied. These compounds were not virucidal and had no measurable effect on the adsorption of virus to the cells at 0 degrees C, whereas they exerted an inhibitory effect on viral antigen synthesis when incubated with the infected cells during HAV multiplication. Among the substances tested, 6,4'-dichloroflavan and 6,4'-dichloroisoflavan showed the highest activity. These compounds are postulated to interact with an early stage (penetration and/or uncoating) of HAV infection.

Superti, F., Seganti, L., Orsi, N., Divizia, M., Gabrieli, R., Panà, A., et al. (1989). Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus. ANTIVIRAL RESEARCH, 11(5-6), 247-254.

Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus

DIVIZIA, MAURIZIO;GABRIELI, ROSANNA;
1989-01-01

Abstract

The effect of 6,4'-dichloroflavan and of isoflavan and isoflavene derivatives on hepatitis A virus (HAV) infection in a monkey cell line (Frp/3 cells) was studied. These compounds were not virucidal and had no measurable effect on the adsorption of virus to the cells at 0 degrees C, whereas they exerted an inhibitory effect on viral antigen synthesis when incubated with the infected cells during HAV multiplication. Among the substances tested, 6,4'-dichloroflavan and 6,4'-dichloroisoflavan showed the highest activity. These compounds are postulated to interact with an early stage (penetration and/or uncoating) of HAV infection.
1989
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/42 - IGIENE GENERALE E APPLICATA
English
Virus Replication; Molecular Structure; Flavonoids; Dose-Response Relationship, Drug; Humans; Hepatovirus; Fluorescent Antibody Technique; Antiviral Agents; Cell Line
Superti, F., Seganti, L., Orsi, N., Divizia, M., Gabrieli, R., Panà, A., et al. (1989). Effect of isoflavans and isoflavenes on the infection of Frp/3 cells by hepatitis A virus. ANTIVIRAL RESEARCH, 11(5-6), 247-254.
Superti, F; Seganti, L; Orsi, N; Divizia, M; Gabrieli, R; Panà, A; Stein, M
Articolo su rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/66587
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