Background: Alteration of the amyloid precursor protein (APP) forms ratio has been described in the platelets of patients with dementia of Alzheimer type (DAT) and in a subset of subjects with mild cognitive impairment (MCI). Objective: To evaluate the potential role of the platelet APP forms ratio in predicting progression from MCI to DAT. Design: Thirty subjects with MCI underwent a clinical and neuropsychological examination and a determination of the platelet APP forms ratio. Subjects were followed up periodically for 2 years, and the progression to dementia was evaluated. Setting: Community population-based sample of patients admitted for memory complaints. Results: Patients who progressed to DAT at the 2-year follow-up (n = 12) showed a significant decrease of baseline platelet APP forms ratio values (mean ± SD, 0.36 ± 0.28) compared with stable MCI subjects (mean ± SD, 0.73 ± 0.32) (P<01) and patients who developed other types of dementia (mean ± SD, 0.83 ± 0.27) (P=.03). By fixing a cutoff score of 0.6, 10 (83%) of the 12 DAT patients showed baseline values below the cut-off, whereas 10 (71%) of 14 subjects who either developed non-Alzheimer-type dementia or maintained cognitive functions had values in the normal range. Conclusion: Mild cognitive impairment is a major risk factor for DAT, and Alzheimer disease-related pathological changes can be identified in patients converting to DAT within a 2-year follow-up.

Borroni, B., Colciaghi, F., Caltagirone, C., Rozzini, L., Broglio, L., Cattabeni, F., et al. (2003). Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia Alzheimer type - A 2-year follow-up study. ARCHIVES OF NEUROLOGY, 60(12), 1740-1744 [10.1001/archneur.60.12.1740].

Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia Alzheimer type - A 2-year follow-up study

CALTAGIRONE, CARLO;
2003

Abstract

Background: Alteration of the amyloid precursor protein (APP) forms ratio has been described in the platelets of patients with dementia of Alzheimer type (DAT) and in a subset of subjects with mild cognitive impairment (MCI). Objective: To evaluate the potential role of the platelet APP forms ratio in predicting progression from MCI to DAT. Design: Thirty subjects with MCI underwent a clinical and neuropsychological examination and a determination of the platelet APP forms ratio. Subjects were followed up periodically for 2 years, and the progression to dementia was evaluated. Setting: Community population-based sample of patients admitted for memory complaints. Results: Patients who progressed to DAT at the 2-year follow-up (n = 12) showed a significant decrease of baseline platelet APP forms ratio values (mean ± SD, 0.36 ± 0.28) compared with stable MCI subjects (mean ± SD, 0.73 ± 0.32) (P<01) and patients who developed other types of dementia (mean ± SD, 0.83 ± 0.27) (P=.03). By fixing a cutoff score of 0.6, 10 (83%) of the 12 DAT patients showed baseline values below the cut-off, whereas 10 (71%) of 14 subjects who either developed non-Alzheimer-type dementia or maintained cognitive functions had values in the normal range. Conclusion: Mild cognitive impairment is a major risk factor for DAT, and Alzheimer disease-related pathological changes can be identified in patients converting to DAT within a 2-year follow-up.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
English
amyloid precursor protein; biological marker; adult; aged; Alzheimer disease; article; clinical article; clinical examination; cognition; cognitive defect; controlled study; disease course; disease severity; evaluation; female; follow up; human; male; memory disorder; neuropsychological test; population research; prediction; priority journal; protein analysis; protein determination; risk factor; scoring system; thrombocyte anomaly; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Blood Platelets; Cognition Disorders; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Prognosis; Risk Factors
Borroni, B., Colciaghi, F., Caltagirone, C., Rozzini, L., Broglio, L., Cattabeni, F., et al. (2003). Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia Alzheimer type - A 2-year follow-up study. ARCHIVES OF NEUROLOGY, 60(12), 1740-1744 [10.1001/archneur.60.12.1740].
Borroni, B; Colciaghi, F; Caltagirone, C; Rozzini, L; Broglio, L; Cattabeni, F; Di Luca, M; Padovani, A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/66043
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