The proto-oncogene c-kit encodes a transmembrane protein tyrosine kinase receptor. The c-kit gene has recently been shown to be allelic with the W locus. Mutations at the white spotting locus (W) affect various aspects of hematopoiesis, melanogenesis and gametogenesis during development and in the adult animal. We have investigated the expression of the proto-oncogene c-kit in mouse testicular cell populations. The c-kit mRNA was found to be expressed at high levels in spermatogonia, and at lower levels in meiotic pachytene spermatocytes. Moreover, two novel testis-specific c-kit transcripts of 3.5 and 2.3 kb are present in postmeiotic haploid germ cells. These results suggest a role of c-kit not only during testis development in the embryo, but also throughout all stages of male germ cell development after birth.

Sorrentino, V., Giorgi, M., Geremia, R., Besmer, P., Rossi, P. (1991). Expression of the c-kit proto-oncogene in the murine male germ cells. ONCOGENE, 6(1), 149-151.

Expression of the c-kit proto-oncogene in the murine male germ cells

GEREMIA, RAFFAELE;ROSSI, PELLEGRINO
1991-01-01

Abstract

The proto-oncogene c-kit encodes a transmembrane protein tyrosine kinase receptor. The c-kit gene has recently been shown to be allelic with the W locus. Mutations at the white spotting locus (W) affect various aspects of hematopoiesis, melanogenesis and gametogenesis during development and in the adult animal. We have investigated the expression of the proto-oncogene c-kit in mouse testicular cell populations. The c-kit mRNA was found to be expressed at high levels in spermatogonia, and at lower levels in meiotic pachytene spermatocytes. Moreover, two novel testis-specific c-kit transcripts of 3.5 and 2.3 kb are present in postmeiotic haploid germ cells. These results suggest a role of c-kit not only during testis development in the embryo, but also throughout all stages of male germ cell development after birth.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/16
English
Con Impact Factor ISI
RNA, Messenger; Animals; Proto-Oncogene Proteins; Blotting, Northern; Proto-Oncogene Proteins c-kit; Spermatozoa; Gene Expression; Protein-Tyrosine Kinases; Mice; Spermatocytes; Male; Spermatogonia
Sorrentino, V., Giorgi, M., Geremia, R., Besmer, P., Rossi, P. (1991). Expression of the c-kit proto-oncogene in the murine male germ cells. ONCOGENE, 6(1), 149-151.
Sorrentino, V; Giorgi, M; Geremia, R; Besmer, P; Rossi, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/65852
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