We have cloned a novel c-kit mRNA of 3.2 kb expressed in postmeiotic male germ cells. This transcript initiates in the genomic region immediately upstream of the exon coding for the second box of the split c-kit tyrosine kinase domain. The open reading frame (ORF) contains 12 novel amino acids in frame with the C-terminal 190 amino acids of the c-kit protein. It lacks therefore the upstream region in the 5.5-kb c-kit mRNA encoding the extracellular and transmembrane domain, the ATP-binding site and the kinase insert domain present in the c-kit protein.

Rossi, P., Marziali, G., Albanesi, C., Charlesworth, A., Geremia, R., Sorrentino, V. (1992). A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids. DEVELOPMENTAL BIOLOGY, 152(1), 203-207 [10.1016/0012-1606(92)90172-D].

A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids

ROSSI, PELLEGRINO;GEREMIA, RAFFAELE;
1992

Abstract

We have cloned a novel c-kit mRNA of 3.2 kb expressed in postmeiotic male germ cells. This transcript initiates in the genomic region immediately upstream of the exon coding for the second box of the split c-kit tyrosine kinase domain. The open reading frame (ORF) contains 12 novel amino acids in frame with the C-terminal 190 amino acids of the c-kit protein. It lacks therefore the upstream region in the 5.5-kb c-kit mRNA encoding the extracellular and transmembrane domain, the ATP-binding site and the kinase insert domain present in the c-kit protein.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/16
English
Con Impact Factor ISI
Animals; Proto-Oncogene Proteins c-kit; Amino Acid Sequence; Mice; Chromosome Mapping; Cloning, Molecular; RNA, Messenger; Base Sequence; Proto-Oncogene Proteins; Spermatids; Introns; Molecular Sequence Data; Male
Rossi, P., Marziali, G., Albanesi, C., Charlesworth, A., Geremia, R., Sorrentino, V. (1992). A novel c-kit transcript, potentially encoding a truncated receptor, originates within a kit gene intron in mouse spermatids. DEVELOPMENTAL BIOLOGY, 152(1), 203-207 [10.1016/0012-1606(92)90172-D].
Rossi, P; Marziali, G; Albanesi, C; Charlesworth, A; Geremia, R; Sorrentino, V
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/65849
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