The c-kit gene plays a fundamental role during the establishment, the maintenance and the function of germ cells. In the embryonal gonad the c-kit tyrosine kinase receptor and its ligand Stem Cell Factor (SCF) are required for the survival and proliferation of primordial germ cells. In the postnatal animal, c-kit/SCF are required for the production of the mature gametes in response to gonadotropic hormones, i.e. for the survival and/or proliferation of the only proliferating germ cells of the testis, the spermatogonia, and for the growth and maturation of the oocytes. Finally, a truncated c-kit product, tr-kit, specifically expressed in post-meiotic stages of spermatogenesis and present in mature spermatozoa, causes parthenogenetic activation when microinjected into mouse eggs, suggesting that it might play a role in the final function of the gametes, fertilization.

Sette, C., DOLCI IANNINI, S., Geremia, R., Rossi, P. (2000). The role of stem cell factor and of alternative c-kit gene products in the establishment, maintenance and function of germ cells. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 44(6), 599-608.

The role of stem cell factor and of alternative c-kit gene products in the establishment, maintenance and function of germ cells

SETTE, CLAUDIO;DOLCI IANNINI, SUSANNA;GEREMIA, RAFFAELE;ROSSI, PELLEGRINO
2000-01-01

Abstract

The c-kit gene plays a fundamental role during the establishment, the maintenance and the function of germ cells. In the embryonal gonad the c-kit tyrosine kinase receptor and its ligand Stem Cell Factor (SCF) are required for the survival and proliferation of primordial germ cells. In the postnatal animal, c-kit/SCF are required for the production of the mature gametes in response to gonadotropic hormones, i.e. for the survival and/or proliferation of the only proliferating germ cells of the testis, the spermatogonia, and for the growth and maturation of the oocytes. Finally, a truncated c-kit product, tr-kit, specifically expressed in post-meiotic stages of spermatogenesis and present in mature spermatozoa, causes parthenogenetic activation when microinjected into mouse eggs, suggesting that it might play a role in the final function of the gametes, fertilization.
2000
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/16 - ANATOMIA UMANA
English
Con Impact Factor ISI
Animals; Apoptosis; Proto-Oncogene Proteins c-kit; Mice; Stem Cell Factor; Models, Biological; Cell Survival; Fertilization; Germ Cells; Alternative Splicing; Meiosis; Mitosis; Oocytes; Cell Line; Female; Male; Cell Division
Sette, C., DOLCI IANNINI, S., Geremia, R., Rossi, P. (2000). The role of stem cell factor and of alternative c-kit gene products in the establishment, maintenance and function of germ cells. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 44(6), 599-608.
Sette, C; DOLCI IANNINI, S; Geremia, R; Rossi, P
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/65816
Citazioni
  • ???jsp.display-item.citation.pmc??? 37
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact