Specific binding of [125I]insulin to circulating monocytes and erythrocytes from nine normal menstruating women and nine normal men was determined during a 28-day period (one sample every 7 days). In women, insulin binding was higher to both monocytes (P less than 0.001) and erythrocytes (P less than 0.02) in the follicular phase than in the luteal phase. In men, insulin binding to monocytes was similar to the follicular phase values for women; however, insulin binding to erythrocytes from men showed higher values than insulin binding to erythrocytes from women in both the follicular (P less than 0.001) and luteal (P less than 0.001) phases. These differences were due primarily to changes in receptor concentration rather than receptor affinity. An inverse relationship was found between insulin binding to monocytes and levels of 17 beta-estradiol, progesterone, and 17 alpha-hydroxyprogesterone; this relationship was not observed in insulin binding to erythrocytes. The present data, therefore, suggest that sex hormones may play a role in the control of insulin receptors. Furthermore, it appears that other factors exist during the follicular phase that lower insulin binding to erythrocyte insulin receptors. If insulin receptors on circulating cells reflect the behavior of the main insulin target tissues, the present data might in part explain the reduction in glucose tolerance reported by various authors in the second half of the menstrual cycle.

Bertoli, A., De Pirro, R., Fusco, A., Greco, A., Magnatta, R., Lauro, R. (1980). Differences in insulin receptors between men and menstruating women and influence of sex hormones on insulin binding during the menstrual cycle. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 50(2), 246-250 [doi: 10.1210/jcem-50-2-246].

Differences in insulin receptors between men and menstruating women and influence of sex hormones on insulin binding during the menstrual cycle

BERTOLI, ALDO;FUSCO, ANGELO;LAURO, RENATO
1980-02-01

Abstract

Specific binding of [125I]insulin to circulating monocytes and erythrocytes from nine normal menstruating women and nine normal men was determined during a 28-day period (one sample every 7 days). In women, insulin binding was higher to both monocytes (P less than 0.001) and erythrocytes (P less than 0.02) in the follicular phase than in the luteal phase. In men, insulin binding to monocytes was similar to the follicular phase values for women; however, insulin binding to erythrocytes from men showed higher values than insulin binding to erythrocytes from women in both the follicular (P less than 0.001) and luteal (P less than 0.001) phases. These differences were due primarily to changes in receptor concentration rather than receptor affinity. An inverse relationship was found between insulin binding to monocytes and levels of 17 beta-estradiol, progesterone, and 17 alpha-hydroxyprogesterone; this relationship was not observed in insulin binding to erythrocytes. The present data, therefore, suggest that sex hormones may play a role in the control of insulin receptors. Furthermore, it appears that other factors exist during the follicular phase that lower insulin binding to erythrocyte insulin receptors. If insulin receptors on circulating cells reflect the behavior of the main insulin target tissues, the present data might in part explain the reduction in glucose tolerance reported by various authors in the second half of the menstrual cycle.
feb-1980
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - ENDOCRINOLOGIA
Settore MED/09 - MEDICINA INTERNA
English
Luteinizing Hormone; Sex Factors; Progesterone; Humans; Erythrocytes; Estradiol; Insulin; Follicle Stimulating Hormone; Hydroxyprogesterones; Kinetics; Adult; Menstruation; Monocytes; Receptor, Insulin; Female; Male
Bertoli, A., De Pirro, R., Fusco, A., Greco, A., Magnatta, R., Lauro, R. (1980). Differences in insulin receptors between men and menstruating women and influence of sex hormones on insulin binding during the menstrual cycle. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 50(2), 246-250 [doi: 10.1210/jcem-50-2-246].
Bertoli, A; De Pirro, R; Fusco, A; Greco, A; Magnatta, R; Lauro, R
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/65734
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 109
  • ???jsp.display-item.citation.isi??? ND
social impact