It has been previously demonstrated that DBI is present in endocrine pancreas and it is able to inhibit insulin release in isolated rat islets. Its mechanism of action has been investigated, demonstrating the possible involvement of cAMP and ATP-dependent K(+) channels. DB1(33-50), a post-translational product of DBI, is also able to inhibit insulin release, but its action has not been characterized. In the present study, we have investigated the presence of DBI mRNA in pancreas, islets and cultured ß cells. The possible mechanism of action of DBI(33-50) and the involvement of BZ/GABA(A) receptors has been studied.

Borboni, P., Magnaterra, R., Porzio, O., Fusco, A., Sesti, G., Bertoli, A., et al. (1995). DBI mRNA is expressed in endocrine pancreas and its post-translational product DBI(33-50) inhibits insulin release. ENDOCRINE, 3(4), 267-271 [10.1007/BF03021404].

DBI mRNA is expressed in endocrine pancreas and its post-translational product DBI(33-50) inhibits insulin release

BORBONI, PATRIZIA;MAGNATERRA, ROBERTA;PORZIO, OTTAVIA;FUSCO, ANGELO;SESTI, GIORGIO;BERTOLI, ALDO;LAURO, RENATO;
1995-04-01

Abstract

It has been previously demonstrated that DBI is present in endocrine pancreas and it is able to inhibit insulin release in isolated rat islets. Its mechanism of action has been investigated, demonstrating the possible involvement of cAMP and ATP-dependent K(+) channels. DB1(33-50), a post-translational product of DBI, is also able to inhibit insulin release, but its action has not been characterized. In the present study, we have investigated the presence of DBI mRNA in pancreas, islets and cultured ß cells. The possible mechanism of action of DBI(33-50) and the involvement of BZ/GABA(A) receptors has been studied.
apr-1995
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/09 - MEDICINA INTERNA
Settore MED/13 - ENDOCRINOLOGIA
English
Borboni, P., Magnaterra, R., Porzio, O., Fusco, A., Sesti, G., Bertoli, A., et al. (1995). DBI mRNA is expressed in endocrine pancreas and its post-translational product DBI(33-50) inhibits insulin release. ENDOCRINE, 3(4), 267-271 [10.1007/BF03021404].
Borboni, P; Magnaterra, R; Porzio, O; Fusco, A; Sesti, G; Bertoli, A; Lauro, R; Marlier, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/65732
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