The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.
Tancredi, V., Zona, C., Velotti, F., Eusebi, F., Santoni, A. (1990). Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus. BRAIN RESEARCH, 525(1), 149-151 [10.1016/0006-8993(90)91331-A].
Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus
TANCREDI, VIRGINIA;ZONA, CRISTINA;
1990-08-13
Abstract
The effects of recombinant interleukin-2 (rIL-2) on the potentiation of the synaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation (LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
