The synthesiso of HEPT-derived tru ncated reversei isoxazolidinyl nucleosides( shown)is reported. These compounds represent the first exampleso f isoxazolidinebse aringa pyrimidine scaffold at the C-3 position usinga glycoside-typeli nkage.B iological evaluation showed that some of the derivativesa ct as non-nucleosidien hibitors of HIV-1r everset ranscriptasew, ith an efficacy comparable to that of Nevirapine but with reduced toxicity.
Romeo, R., Giofrè, S., Macchi, B., Balestrieri, E., Mastino, A., Merino, P., et al. (2012). Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors. CHEMMEDCHEM, 7(4), 565-569 [10.1002/cmdc.201200022].
Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors
MACCHI, BEATRICE;BALESTRIERI, EMANUELA;
2012-01-01
Abstract
The synthesiso of HEPT-derived tru ncated reversei isoxazolidinyl nucleosides( shown)is reported. These compounds represent the first exampleso f isoxazolidinebse aringa pyrimidine scaffold at the C-3 position usinga glycoside-typeli nkage.B iological evaluation showed that some of the derivativesa ct as non-nucleosidien hibitors of HIV-1r everset ranscriptasew, ith an efficacy comparable to that of Nevirapine but with reduced toxicity.| File | Dimensione | Formato | |
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