Background: Endothelial dysfunction is a common condition in many microvascular diseases, such as Age-related Macular Degeneration (AMD) and Peripheral Arterial Occlusive Disease (PAOD). Rheopheresis therapy improves ematic viscosity, shear stress and endothelial function while decreasing fibrinogen, LDL-cholesterol and alpha-2-macroglobulin levels. Objective: To evaluate the therapeutic efficacy of rheopheresis in patients with microcirculatory diseases. Materials and Methods: Eight patients (7 male and 1 female) were treated with rheopheresis: 3 males were affected by AMD, 4 male and 1 female by uremia and PAOD. We used Membrane Differential Filtration (MDF) with an ethinylvinylalcohol copolymer membrane as plasmafiltrator Patients with AMD were treated once a week for ten weeks. Patients affected with PAOD were treated twice weekly for 3 weeks and then were placed on a once-a-week program. Results: In all treated patients with AMD, visual acuity improved. In all patients affected with PAOD, we observed a complete resolution of pain; 3 out of 5 had a complete remission of ulcers. There was partial reduction of ulcers in the other patients and no adverse effects were observed. Conclusion: Rheopheresis is a safe, effective form of hemorheotherapy.
|Tipologia:||Articolo su rivista|
|Citazione:||Ferrannini, M., Vischini, G., Staffolani, E., Scaccia, F., Miani, N., Parravano, M.C., et al. (2007). Rheopheresis in vascular diseases. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 30(10), 923-929.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2007|
|Titolo:||Rheopheresis in vascular diseases|
|Autori interni:||DI DANIELE, NICOLA |
|Autori:||Ferrannini, M; Vischini, G; Staffolani, E; Scaccia, F; Miani, N; Parravano, MC; Louis, MM; Splendiani, G; Di Daniele, N|
|Appare nelle tipologie:||01 - Articolo su rivista|
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